Abstract
This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.
| Original language | English (US) |
|---|---|
| Journal | Virchows Archiv |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Indolent lymphoproliferative disorders
- Primary gastrointestinal
- T cell lymphomas
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology
Cite this
Update on lymphoproliferative disorders of the gastrointestinal tract : disease spectrum from indolent lymphoproliferations to aggressive lymphomas. / Moreno, Santiago Montes; King, Rebecca L.; Oschlies, Ilske; Ponzoni, Maurilio; Goodlad, John R.; Dotlic, Snjezana; Traverse-Glehen, Alexandra; Ott, German; Ferry, Judith A.; Calaminici, Maria.
In: Virchows Archiv, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Update on lymphoproliferative disorders of the gastrointestinal tract
T2 - disease spectrum from indolent lymphoproliferations to aggressive lymphomas
AU - Moreno, Santiago Montes
AU - King, Rebecca L.
AU - Oschlies, Ilske
AU - Ponzoni, Maurilio
AU - Goodlad, John R.
AU - Dotlic, Snjezana
AU - Traverse-Glehen, Alexandra
AU - Ott, German
AU - Ferry, Judith A.
AU - Calaminici, Maria
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.
AB - This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.
KW - Indolent lymphoproliferative disorders
KW - Primary gastrointestinal
KW - T cell lymphomas
UR - http://www.scopus.com/inward/record.url?scp=85075875644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075875644&partnerID=8YFLogxK
U2 - 10.1007/s00428-019-02704-8
DO - 10.1007/s00428-019-02704-8
M3 - Review article
C2 - 31773249
AN - SCOPUS:85075875644
JO - Virchows Archiv
JF - Virchows Archiv
SN - 0945-6317
ER -