Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas

Santiago Montes Moreno, Rebecca L. King, Ilske Oschlies, Maurilio Ponzoni, John R. Goodlad, Snjezana Dotlic, Alexandra Traverse-Glehen, German Ott, Judith A. Ferry, Maria Calaminici

Research output: Contribution to journalReview article

Abstract

This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.

Original languageEnglish (US)
JournalVirchows Archiv
DOIs
StateAccepted/In press - Jan 1 2019

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Lymphoproliferative Disorders
Gastrointestinal Diseases
Gastrointestinal Tract
Lymphoma
Mantle-Cell Lymphoma
B-Cell Lymphoma
Natural Killer Cells
Enteropathy-Associated T-Cell Lymphoma
B-Lymphocytes
T-Lymphocytes
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Molecular Pathology
Non-Hodgkin's Lymphoma
Phenotype
Education

Keywords

  • Indolent lymphoproliferative disorders
  • Primary gastrointestinal
  • T cell lymphomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Update on lymphoproliferative disorders of the gastrointestinal tract : disease spectrum from indolent lymphoproliferations to aggressive lymphomas. / Moreno, Santiago Montes; King, Rebecca L.; Oschlies, Ilske; Ponzoni, Maurilio; Goodlad, John R.; Dotlic, Snjezana; Traverse-Glehen, Alexandra; Ott, German; Ferry, Judith A.; Calaminici, Maria.

In: Virchows Archiv, 01.01.2019.

Research output: Contribution to journalReview article

Moreno, Santiago Montes ; King, Rebecca L. ; Oschlies, Ilske ; Ponzoni, Maurilio ; Goodlad, John R. ; Dotlic, Snjezana ; Traverse-Glehen, Alexandra ; Ott, German ; Ferry, Judith A. ; Calaminici, Maria. / Update on lymphoproliferative disorders of the gastrointestinal tract : disease spectrum from indolent lymphoproliferations to aggressive lymphomas. In: Virchows Archiv. 2019.
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