Unusual presentation of adult metastatic peritoneal medulloblastoma associated with a ventriculoperitoneal shunt: A case study and review of the literature

Paul Magtibay, Jonathan A. Friedman, Ravi D. Rao, Jan Craig Buckner, William Arthur Cliby

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17 Citations (Scopus)

Abstract

Patients with medulloblastoma uncommonly develop extracerebral metastases. We describe an adult patient with the unusual occurrence of intraperitoneal metastases associated with a ventriculoperitoneal (VP) shunt, as well as her subsequent treatment with high-dose chemotherapy and bone marrow transplantation. We review the literature regarding this rare presentation and association of metastatic spread via VP shunt devices. A 37-year-old woman presented with a rapidly enlarging pelvic mass. She had a history of medulloblastoma and had been treated with a combination of surgery, chemotherapy, and radiation 5 years previously, at which time a VP shunt had been placed for cerebrospinal fluid leakage. At laparotomy, she had unresectable intraperitoneal metastatic medulloblastoma. After an excellent response to cyclophosphamide, etoposide, and cisplatin, she underwent a resection of residual disease, followed by high-dose chemotherapy and a bone marrow transplant. We conclude that adult onset medulloblastoma with metastasis to the peritoneal cavity is rare and may be associated with a VP shunt.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalNeuro-Oncology
Volume5
Issue number3
DOIs
StatePublished - Jul 2003

Fingerprint

Ventriculoperitoneal Shunt
Medulloblastoma
Neoplasm Metastasis
Drug Therapy
Peritoneal Cavity
Etoposide
Combination Drug Therapy
Bone Marrow Transplantation
Cyclophosphamide
Laparotomy
Cisplatin
Bone Marrow
Radiation
Transplants
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

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abstract = "Patients with medulloblastoma uncommonly develop extracerebral metastases. We describe an adult patient with the unusual occurrence of intraperitoneal metastases associated with a ventriculoperitoneal (VP) shunt, as well as her subsequent treatment with high-dose chemotherapy and bone marrow transplantation. We review the literature regarding this rare presentation and association of metastatic spread via VP shunt devices. A 37-year-old woman presented with a rapidly enlarging pelvic mass. She had a history of medulloblastoma and had been treated with a combination of surgery, chemotherapy, and radiation 5 years previously, at which time a VP shunt had been placed for cerebrospinal fluid leakage. At laparotomy, she had unresectable intraperitoneal metastatic medulloblastoma. After an excellent response to cyclophosphamide, etoposide, and cisplatin, she underwent a resection of residual disease, followed by high-dose chemotherapy and a bone marrow transplant. We conclude that adult onset medulloblastoma with metastasis to the peritoneal cavity is rare and may be associated with a VP shunt.",
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AU - Rao, Ravi D.

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