Unusual presentation of adult metastatic peritoneal medulloblastoma associated with a ventriculoperitoneal shunt: A case study and review of the literature

Paul Magtibay, Jonathan A. Friedman, Ravi D. Rao, Jan Craig Buckner, William Arthur Cliby

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17 Scopus citations

Abstract

Patients with medulloblastoma uncommonly develop extracerebral metastases. We describe an adult patient with the unusual occurrence of intraperitoneal metastases associated with a ventriculoperitoneal (VP) shunt, as well as her subsequent treatment with high-dose chemotherapy and bone marrow transplantation. We review the literature regarding this rare presentation and association of metastatic spread via VP shunt devices. A 37-year-old woman presented with a rapidly enlarging pelvic mass. She had a history of medulloblastoma and had been treated with a combination of surgery, chemotherapy, and radiation 5 years previously, at which time a VP shunt had been placed for cerebrospinal fluid leakage. At laparotomy, she had unresectable intraperitoneal metastatic medulloblastoma. After an excellent response to cyclophosphamide, etoposide, and cisplatin, she underwent a resection of residual disease, followed by high-dose chemotherapy and a bone marrow transplant. We conclude that adult onset medulloblastoma with metastasis to the peritoneal cavity is rare and may be associated with a VP shunt.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalNeuro-Oncology
Volume5
Issue number3
DOIs
StatePublished - Jul 2003

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

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