Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation

Ayca Dundar, Jason R. Young, Doris E. Wenger, Carrie Y. Inwards, Stephen M. Broski

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Diffuse-type tenosynovial giant cell tumor (TSGCT) is a rare, locally aggressive neoplasm. It most commonly occurs in the knee, followed by the hip, and has distinctive imaging features, including mass-like foci of low T2 signal intensity, “blooming” on gradient-echo MRI, and pronounced uptake on FDG PET/CT. Histologically, TSGCT demonstrates a neoplastic population of mononuclear cells admixed with hemosiderin-laden macrophages, foamy histiocytes, inflammatory cells, and osteoclast-like giant cells. In cases where diffuse-type TSGCT presents in an uncommon location or with atypical features, the imaging diagnosis may be challenging. Furthermore, because of its polymorphous appearance, it may be mistaken microscopically for other neoplastic and non-neoplastic histiocytic lesions. Herein, we present two cases of diffuse-type TSGCT presenting as large masses, and underscore the importance of radiologic-pathologic correlation for accurate diagnosis.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalSkeletal Radiology
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • Histiocytosis
  • Pigmented villonodular synovitis
  • Tenosynovial giant cell tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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