Unusual malignant glioneuronal tumors of the cerebrum of adults

A clinicopathologic study of three cases

Fausto J. Rodriguez, Bernd W. Scheithauer, John D Port

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Malignant glioneuronal tumors of the brain are rare and poorly characterized. Herein, we report the clinicopathologic features of three examples with unusual morphologies including both glial and neuronal differentiation. Hematoxylin and eosin-stained slides were reviewed in all cases. Immunohistochemical stains were performed on formalin-fixed, paraffin-embedded sections. Transmission electron microscopy (EM) was performed on both formalin-fixed (n = 1) and paraffin embedded tissue (n = 2). The immunogold technique for localization of GFAP was also performed. Two patients were male and one was female, age 66, 84, and 34 years, respectively. Radiologic studies demonstrated hyperdensity on CT (n = 3), multicentricity (n = 2), and a cortical based solid component with a cystic extension into underlying white matter (n = 2). At surgery, all three tumors were superficial and relatively circumscribed. Histologically, they were composed of large epithelioid cells (n = 3), spindle cells (n = 1), and poorly differentiated smaller cells with high nuclear/cytoplasmic ratios (n = 1). Brisk mitotic activity and coagulative non-palisading necrosis were present in all cases. The tumors were immunopositive for GFAP (n = 3), S-100 (n = 3), synaptophysin (n = 3), chromogranin (n = 3), Neu-N (n = 2), and neurofilament protein (n = 2). Stains for EMA were negative. EM demonstrated convincing neurosecretory granules in one case, some in filament-containing cells immunogold labeled for GFAP. Two patients expired 3-5 weeks after surgery. True malignant neoplasms with glial and neuronal differentiation do occur in the central nervous system of adults and may pursue a highly aggressive course. The use of minimal diagnostic criteria, e.g., immunoreactivity for a single antigen like neurofilament protein, may not be sufficient and should be discouraged.

Original languageEnglish (US)
Pages (from-to)727-737
Number of pages11
JournalActa Neuropathologica
Volume112
Issue number6
DOIs
StatePublished - Dec 2006

Fingerprint

Cerebrum
Neurofilament Proteins
Neuroglia
Paraffin
Formaldehyde
Coloring Agents
Chromogranins
Epithelioid Cells
Neoplasms
Synaptophysin
Hematoxylin
Eosine Yellowish-(YS)
Transmission Electron Microscopy
Brain Neoplasms
Electron Microscopy
Necrosis
Central Nervous System
Immunohistochemistry
Antigens

Keywords

  • Brain
  • Glioma
  • Glioneuronal
  • Immunohistochemistry
  • Neuronal differentiation
  • Neuronal tumor

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Unusual malignant glioneuronal tumors of the cerebrum of adults : A clinicopathologic study of three cases. / Rodriguez, Fausto J.; Scheithauer, Bernd W.; Port, John D.

In: Acta Neuropathologica, Vol. 112, No. 6, 12.2006, p. 727-737.

Research output: Contribution to journalArticle

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