Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy

Andrew B McKeon, Keith Anthony Josephs, Kevin J. Klos, Kathleen Hecksel, James Howard Bower, J. Michael Bostwick, J. Eric Ahlskog

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Unusual compulsive behaviors (weighing, card and video game playing, fishing, gardening, intense interest in established hobbies, locking and unlocking doors, repetitive dressing and undressing) occurred in relation to dopamine agonist therapy (six patients) and levodopa therapy (one patient) in seven patients with parkinsonism (seven Parkinson's disease, one multiple system atrophy). These behaviors occurred in tandem with pathological gambling, hypersexuality, compulsive eating, compulsive shopping or punding in six of the seven cases. Obsessive thoughts were present in one patient, with no prior history of obsessive-compulsive disorder. The simultaneous occurrence of these phenomenologically distinct behaviors in this group of patients suggests that a broad spectrum of psychopathology may occur in this context and should be monitored for in routine neurological practice.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalParkinsonism and Related Disorders
Volume13
Issue number8
DOIs
StatePublished - Dec 2007

Fingerprint

Compulsive Behavior
Multiple System Atrophy
Dopamine Agonists
Parkinson Disease
Gardening
Hobbies
Therapeutics
Video Games
Gambling
Obsessive-Compulsive Disorder
Parkinsonian Disorders
Levodopa
Bandages
Psychopathology
Eating

Keywords

  • Compulsions
  • Dopamine agonists

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

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abstract = "Unusual compulsive behaviors (weighing, card and video game playing, fishing, gardening, intense interest in established hobbies, locking and unlocking doors, repetitive dressing and undressing) occurred in relation to dopamine agonist therapy (six patients) and levodopa therapy (one patient) in seven patients with parkinsonism (seven Parkinson's disease, one multiple system atrophy). These behaviors occurred in tandem with pathological gambling, hypersexuality, compulsive eating, compulsive shopping or punding in six of the seven cases. Obsessive thoughts were present in one patient, with no prior history of obsessive-compulsive disorder. The simultaneous occurrence of these phenomenologically distinct behaviors in this group of patients suggests that a broad spectrum of psychopathology may occur in this context and should be monitored for in routine neurological practice.",
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AU - Bower, James Howard

AU - Bostwick, J. Michael

AU - Eric Ahlskog, J.

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