Unusual compulsive behaviors primarily related to dopamine agonist therapy in Parkinson's disease and multiple system atrophy

Andrew McKeon, Keith A. Josephs, Kevin J. Klos, Kathleen Hecksel, James H. Bower, J. Michael Bostwick, J. Eric Ahlskog

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Unusual compulsive behaviors (weighing, card and video game playing, fishing, gardening, intense interest in established hobbies, locking and unlocking doors, repetitive dressing and undressing) occurred in relation to dopamine agonist therapy (six patients) and levodopa therapy (one patient) in seven patients with parkinsonism (seven Parkinson's disease, one multiple system atrophy). These behaviors occurred in tandem with pathological gambling, hypersexuality, compulsive eating, compulsive shopping or punding in six of the seven cases. Obsessive thoughts were present in one patient, with no prior history of obsessive-compulsive disorder. The simultaneous occurrence of these phenomenologically distinct behaviors in this group of patients suggests that a broad spectrum of psychopathology may occur in this context and should be monitored for in routine neurological practice.

Original languageEnglish (US)
Pages (from-to)516-519
Number of pages4
JournalParkinsonism and Related Disorders
Volume13
Issue number8
DOIs
StatePublished - Dec 1 2007

Keywords

  • Compulsions
  • Dopamine agonists

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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