Unusual Aspects of Acute Q Fever-Associated Hepatitis

STEVEN H. YALE; PIET C. DE GROEN; JULIUS D. TOOSON; PAUL J. KURTIN

doi:10.1016/S0025-6196(12)61097-0

Unusual Aspects of Acute Q Fever-Associated Hepatitis

STEVEN H. YALE, PIET C. DE GROEN, JULIUS D. TOOSON, PAUL J. KURTIN

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Abstract

We describe a 37-year-old farmer with a 3-week history of fevers and hepatitis, in whom Q fever was diagnosed. The diagnosis was based on the findings of characteristic “ring” granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests to Coxiella burnetii. Unusual aspects of this case included (1) relatively low complement-fixation antibody titers, (2) prolonged prothrombin time, (3) false-positive results of a serologic test for the human immunodeficiency virus (HIV), and (4) ring granulomas that progressed to atypical granulomas in biopsy specimens.

Original language	English (US)
Pages (from-to)	769-773
Number of pages	5
Journal	Mayo Clinic proceedings
Volume	69
Issue number	8
DOIs	https://doi.org/10.1016/S0025-6196(12)61097-0
State	Published - 1994

Keywords

AIDS
ELISA
HIV
acquired immunodeficiency syndrome
enzyme-linked immunosorbent assay
human immunodeficiency virus

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0025-6196(12)61097-0

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title = "Unusual Aspects of Acute Q Fever-Associated Hepatitis",

abstract = "We describe a 37-year-old farmer with a 3-week history of fevers and hepatitis, in whom Q fever was diagnosed. The diagnosis was based on the findings of characteristic “ring” granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests to Coxiella burnetii. Unusual aspects of this case included (1) relatively low complement-fixation antibody titers, (2) prolonged prothrombin time, (3) false-positive results of a serologic test for the human immunodeficiency virus (HIV), and (4) ring granulomas that progressed to atypical granulomas in biopsy specimens.",

keywords = "AIDS, ELISA, HIV, acquired immunodeficiency syndrome, enzyme-linked immunosorbent assay, human immunodeficiency virus",

author = "YALE, {STEVEN H.} and {DE GROEN}, {PIET C.} and TOOSON, {JULIUS D.} and KURTIN, {PAUL J.}",

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AU - YALE, STEVEN H.

AU - DE GROEN, PIET C.

AU - TOOSON, JULIUS D.

AU - KURTIN, PAUL J.

PY - 1994

Y1 - 1994

N2 - We describe a 37-year-old farmer with a 3-week history of fevers and hepatitis, in whom Q fever was diagnosed. The diagnosis was based on the findings of characteristic “ring” granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests to Coxiella burnetii. Unusual aspects of this case included (1) relatively low complement-fixation antibody titers, (2) prolonged prothrombin time, (3) false-positive results of a serologic test for the human immunodeficiency virus (HIV), and (4) ring granulomas that progressed to atypical granulomas in biopsy specimens.

AB - We describe a 37-year-old farmer with a 3-week history of fevers and hepatitis, in whom Q fever was diagnosed. The diagnosis was based on the findings of characteristic “ring” granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests to Coxiella burnetii. Unusual aspects of this case included (1) relatively low complement-fixation antibody titers, (2) prolonged prothrombin time, (3) false-positive results of a serologic test for the human immunodeficiency virus (HIV), and (4) ring granulomas that progressed to atypical granulomas in biopsy specimens.

KW - AIDS

KW - ELISA

KW - HIV

KW - acquired immunodeficiency syndrome

KW - enzyme-linked immunosorbent assay

KW - human immunodeficiency virus

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Unusual Aspects of Acute Q Fever-Associated Hepatitis

Abstract

Keywords

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