Untreated type 2 diabetes and its complications are associated with subcortical infarctions

Rosebud O Roberts, Kejal M Kantarci, Yonas Endale Geda, David S Knopman, Scott A. Przybelski, Stephen D. Weigand, Ronald Carl Petersen, Clifford R Jr. Jack

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalDiabetes Care
Volume34
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Cerebral Infarction
Diabetes Complications
Type 2 Diabetes Mellitus
Sex Education
Research Design
Odds Ratio
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Untreated type 2 diabetes and its complications are associated with subcortical infarctions. / Roberts, Rosebud O; Kantarci, Kejal M; Geda, Yonas Endale; Knopman, David S; Przybelski, Scott A.; Weigand, Stephen D.; Petersen, Ronald Carl; Jack, Clifford R Jr.

In: Diabetes Care, Vol. 34, No. 1, 01.2011, p. 184-186.

Research output: Contribution to journalArticle

@article{a698b5987cee4dde99bc7509513077d2,
title = "Untreated type 2 diabetes and its complications are associated with subcortical infarctions",
abstract = "OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39{\%} in case subjects and 29{\%} in control subjects (odds ratio 1.59 [95{\%} CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.",
author = "Roberts, {Rosebud O} and Kantarci, {Kejal M} and Geda, {Yonas Endale} and Knopman, {David S} and Przybelski, {Scott A.} and Weigand, {Stephen D.} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.}",
year = "2011",
month = "1",
doi = "10.2337/dc10-0602",
language = "English (US)",
volume = "34",
pages = "184--186",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "1",

}

TY - JOUR

T1 - Untreated type 2 diabetes and its complications are associated with subcortical infarctions

AU - Roberts, Rosebud O

AU - Kantarci, Kejal M

AU - Geda, Yonas Endale

AU - Knopman, David S

AU - Przybelski, Scott A.

AU - Weigand, Stephen D.

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

PY - 2011/1

Y1 - 2011/1

N2 - OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

AB - OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

UR - http://www.scopus.com/inward/record.url?scp=79951696677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951696677&partnerID=8YFLogxK

U2 - 10.2337/dc10-0602

DO - 10.2337/dc10-0602

M3 - Article

VL - 34

SP - 184

EP - 186

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 1

ER -