Untreated type 2 diabetes and its complications are associated with subcortical infarctions

Rosebud O Roberts, Kejal M Kantarci, Yonas Endale Geda, David S Knopman, Scott A. Przybelski, Stephen D. Weigand, Ronald Carl Petersen, Clifford R Jr. Jack

Research output: Contribution to journalArticle

6 Scopus citations


OBJECTIVE - To investigate the association of type 2 diabetes with subcortical infarctions. RESEARCH DESIGN AND METHODS - We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. RESULTS - The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91-2.75]). The association was stronger in case subjects without treatment (2.60 [1.11- 6.08]) and in case subjects with diabetes-related complications (1.96 [1.02-3.74]) compared with control subjects. CONCLUSIONS - These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalDiabetes Care
Issue number1
StatePublished - Jan 2011


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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