Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis

Laila M. Poisson, Hamid Suhail, Jaspreet Singh, Indrani Datta, Aleksandar Denic, Krzysztof Labuzek, Nasrul Hoda, Ashray Shankar, Ashok Kumar, Mirela Cerghet, Stanton Elias, Robert P. Mohney, Moses Rodriguez, Ramandeep Rattan, Ashutosh K. Mangalam, Shailendra Giri

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21 Scopus citations

Abstract

We performed untargeted metabolomics in plasma of B6 mice with experimental autoimmune encephalitis (EAE) at the chronic phase of the disease in search of an altered metabolic pathway(s). Of 324 metabolites measured, 100 metabolites that mapped to various pathways (mainly lipids) linked to mitochondrial function, inflammation, and membrane stability were observed to be significantly altered between EAE and control (p > 0.05, false discovery rate >0.10). Bioinformatics analysis revealed six metabolic pathways being impacted and altered in EAE, including

Original languageEnglish (US)
Pages (from-to)30697-30712
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number52
DOIs
StatePublished - Dec 25 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Poisson, L. M., Suhail, H., Singh, J., Datta, I., Denic, A., Labuzek, K., Hoda, N., Shankar, A., Kumar, A., Cerghet, M., Elias, S., Mohney, R. P., Rodriguez, M., Rattan, R., Mangalam, A. K., & Giri, S. (2015). Untargeted plasma metabolomics identifies endogenous metabolite with drug-like properties in chronic animal model of multiple sclerosis. Journal of Biological Chemistry, 290(52), 30697-30712. https://doi.org/10.1074/jbc.M115.679068