Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice

Sanjay D. Khare, Harvinder S. Luthra, Chella S. David

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalSeminars in Immunology
Volume10
Issue number1
DOIs
StatePublished - Feb 1998

Fingerprint

Spondylarthropathies
HLA-B27 Antigen
Knockout Mice
Animal Diseases
Enterobacteriaceae
Transgenes
Transgenic Mice
Breeding
Animal Models
Alleles
Bacteria
Antigens
Infection

Keywords

  • Animal model
  • HLA-B27
  • Spondyloarthropathies
  • Transgenic mice

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice. / Khare, Sanjay D.; Luthra, Harvinder S.; David, Chella S.

In: Seminars in Immunology, Vol. 10, No. 1, 02.1998, p. 15-23.

Research output: Contribution to journalArticle

Khare, Sanjay D. ; Luthra, Harvinder S. ; David, Chella S. / Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice. In: Seminars in Immunology. 1998 ; Vol. 10, No. 1. pp. 15-23.
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