Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice

Sanjay D. Khare, Harvinder S. Luthra, Chella S. David

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalSeminars in immunology
Volume10
Issue number1
DOIs
StatePublished - Feb 1998

Keywords

  • Animal model
  • HLA-B27
  • Spondyloarthropathies
  • Transgenic mice

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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