Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

Hader Sanai, Anthony D. Tramontin, Alfredo Quinones-Hinojosa, Nicholas M. Barbaro, Halin Gupta, Sandeep Kunwar, Michael T. Lawton, Michael W. McDermott, Andrew T. Parsa, José Manuel Garcia Verdugo, Mitchel S. Berger, Arturo Alvarez-Buylla

Research output: Contribution to journalArticle

972 Citations (Scopus)

Abstract

The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain, generating thousands of olfactory bulb neurons every day. If the adult human brain contains a comparable germinal region, this could have considerable implications for future neuroregenerative therapy. Stem cells have been isolated from the human brain, but the identity, organization and function of adult neural stem cells in the human SVZ are unknown. Here we describe a ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro. This astrocytic ribbon has not been observed in other vertebrates studied. Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
JournalNature
Volume427
Issue number6976
DOIs
StatePublished - Feb 19 2004
Externally publishedYes

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Neural Stem Cells
Lateral Ventricles
Emigration and Immigration
Astrocytes
Brain
Adult Stem Cells
Olfactory Bulb
Stem Cells
Organizations
Vertebrates
Rodentia
Neurons

ASJC Scopus subject areas

  • General

Cite this

Sanai, H., Tramontin, A. D., Quinones-Hinojosa, A., Barbaro, N. M., Gupta, H., Kunwar, S., ... Alvarez-Buylla, A. (2004). Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature, 427(6976), 740-744. https://doi.org/10.1038/nature02301

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. / Sanai, Hader; Tramontin, Anthony D.; Quinones-Hinojosa, Alfredo; Barbaro, Nicholas M.; Gupta, Halin; Kunwar, Sandeep; Lawton, Michael T.; McDermott, Michael W.; Parsa, Andrew T.; Verdugo, José Manuel Garcia; Berger, Mitchel S.; Alvarez-Buylla, Arturo.

In: Nature, Vol. 427, No. 6976, 19.02.2004, p. 740-744.

Research output: Contribution to journalArticle

Sanai, H, Tramontin, AD, Quinones-Hinojosa, A, Barbaro, NM, Gupta, H, Kunwar, S, Lawton, MT, McDermott, MW, Parsa, AT, Verdugo, JMG, Berger, MS & Alvarez-Buylla, A 2004, 'Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration', Nature, vol. 427, no. 6976, pp. 740-744. https://doi.org/10.1038/nature02301
Sanai, Hader ; Tramontin, Anthony D. ; Quinones-Hinojosa, Alfredo ; Barbaro, Nicholas M. ; Gupta, Halin ; Kunwar, Sandeep ; Lawton, Michael T. ; McDermott, Michael W. ; Parsa, Andrew T. ; Verdugo, José Manuel Garcia ; Berger, Mitchel S. ; Alvarez-Buylla, Arturo. / Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. In: Nature. 2004 ; Vol. 427, No. 6976. pp. 740-744.
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