Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization

Zaraq Khan, Ravi P. Gada, Zaid M. Tabbaa, Shannon K Laughlin-Tommaso, Jani R. Jensen, Charles C. Coddington, Elizabeth A Stewart

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective To assess the effect of unilateral oophorectomy (UO) by assessing ovarian reserve (OVR) and the response to gonadotropin stimulation in women with UO undergoing in vitro fertilization (IVF) compared with the response of the ipsilateral ovary of women without UO. Design Historical cohort study. Setting Academic fertility clinic. Patient(s) Fifty-one women with single ovary compared with a referent group with both ovaries in a 1:2 fashion. Intervention(s) None. Main Outcome Measure(s) Day-3 follicle-stimulating hormone (FSH), estradiol, and antral follicle counts as measures of OVR, and IVF outcomes including number of follicles aspirated and oocytes retrieved. Result(s) The baseline demographics and serum markers of OVR were not different. Referent women had greater follicular yield and oocyte numbers when compared with women with UO; however, when compared with the ipsilateral ovary of the referents, women with UO had a higher antral follicle count and greater follicle and oocyte numbers. In multivariate analyses, the ovary from women with UO was more likely to yield more than the median number of follicles and oocytes than the ipsilateral ovary in referent women. Live-birth rates in both groups were similar. Conclusion(s) Our results suggest that the remaining ovary appears to compensate in follicular yield after UO in women, confirming the animal data. Women with UO can be reassured and appropriately counseled regarding IVF.

Original languageEnglish (US)
Pages (from-to)722-727
Number of pages6
JournalFertility and Sterility
Volume101
Issue number3
DOIs
StatePublished - Mar 2014

Fingerprint

Ovulation Induction
Ovariectomy
Fertilization in Vitro
Ovary
Oocytes
Birth Rate
Live Birth
Follicle Stimulating Hormone
Gonadotropins
Fertility
Estradiol
Cohort Studies
Multivariate Analysis
Biomarkers
Demography
Outcome Assessment (Health Care)

Keywords

  • Compensatory follicular recruitment
  • in vitro fertilization
  • ovarian reserve
  • unilateral oophorectomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Unilateral oophorectomy results in compensatory follicular recruitment in the remaining ovary at time of ovarian stimulation for in vitro fertilization. / Khan, Zaraq; Gada, Ravi P.; Tabbaa, Zaid M.; Laughlin-Tommaso, Shannon K; Jensen, Jani R.; Coddington, Charles C.; Stewart, Elizabeth A.

In: Fertility and Sterility, Vol. 101, No. 3, 03.2014, p. 722-727.

Research output: Contribution to journalArticle

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