Uniform vascular contrast enhancement and reduced contrast medium volume achieved by using exponentially decelerated contrast material injection method

Kyongtae T. Bae, Huy Q. Tran, Jay Heiken

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

PURPOSE: To investigate in computed tomographic (CT) angiography whether an exponentially decelerated contrast medium injection, as compared with a standard constant-rate injection, can facilitate uniform vascular contrast enhancement with a reduced contrast material volume. MATERIALS AND METHODS: CT angiography of the abdominal aorta was performed in 46 subjects by using an exponentially decelerated injection method: 134 mL of contrast medium was injected for 40 seconds, starting at 4.0 mL/sec and decreasing exponentially to 2.7 mL/sec by the end of the injection. Twenty-one of these subjects also underwent CT angiography with a constant-rate injection: 160 mL of contrast medium was injected for 40 seconds at a constant rate of 4 mL/sec. Time-enhancement curves and the magnitude of peak vascular enhancement were measured. Enhancement uniformity was evaluated by using three indexes: (a) duration of contrast enhancement achieved within 80% of the peak (80% DCE), (b) SD of the normalized contrast enhancement (SDNCE) measured from the beginning of spiral CT scanning to the time when the enhancement decreased to a level lower than the beginning level, and (c) slope of the enhancement curve calculated by using linear regression analysis. RESULTS: Exponentially decelerated injection resulted in more uniform enhancement. Mean values generated by using exponentially decelerated versus constant-rate injection in 21 paired comparisons were, respectively, 30.8 seconds ± 5.0 versus 22.6 seconds ± 7.6 for 80% DCE, 0.052 ± 0.017 versus 0.086 ± 0.031 for SDNCE, and 0.47 HU/sec ± 0.70 versus 2.27 HU/sec ± 0.87 for slope (P < .001 for all indexes). Compared with the peak enhancement resulting from the constant-rate injection, that resulting from the exponentially decelerated injection was reduced by a mean of 17.2% ± 10.0. CONCLUSION: Uniform vascular contrast enhancement and reduced contrast medium volume, which are desirable in CT angiography, can be achieved with exponentially decelerated injection.

Original languageEnglish (US)
Pages (from-to)732-736
Number of pages5
JournalRadiology
Volume231
Issue number3
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Contrast Media
Blood Vessels
Injections
Angiography
Matched-Pair Analysis
Abdominal Aorta
Linear Models
Regression Analysis

Keywords

  • Aorta, CT
  • Computed tomography (CT), angiography
  • Computed tomography (CT), contrast enhancement
  • Computed tomography (CT), contrast media
  • Contrast media

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Uniform vascular contrast enhancement and reduced contrast medium volume achieved by using exponentially decelerated contrast material injection method. / Bae, Kyongtae T.; Tran, Huy Q.; Heiken, Jay.

In: Radiology, Vol. 231, No. 3, 01.06.2004, p. 732-736.

Research output: Contribution to journalArticle

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abstract = "PURPOSE: To investigate in computed tomographic (CT) angiography whether an exponentially decelerated contrast medium injection, as compared with a standard constant-rate injection, can facilitate uniform vascular contrast enhancement with a reduced contrast material volume. MATERIALS AND METHODS: CT angiography of the abdominal aorta was performed in 46 subjects by using an exponentially decelerated injection method: 134 mL of contrast medium was injected for 40 seconds, starting at 4.0 mL/sec and decreasing exponentially to 2.7 mL/sec by the end of the injection. Twenty-one of these subjects also underwent CT angiography with a constant-rate injection: 160 mL of contrast medium was injected for 40 seconds at a constant rate of 4 mL/sec. Time-enhancement curves and the magnitude of peak vascular enhancement were measured. Enhancement uniformity was evaluated by using three indexes: (a) duration of contrast enhancement achieved within 80{\%} of the peak (80{\%} DCE), (b) SD of the normalized contrast enhancement (SDNCE) measured from the beginning of spiral CT scanning to the time when the enhancement decreased to a level lower than the beginning level, and (c) slope of the enhancement curve calculated by using linear regression analysis. RESULTS: Exponentially decelerated injection resulted in more uniform enhancement. Mean values generated by using exponentially decelerated versus constant-rate injection in 21 paired comparisons were, respectively, 30.8 seconds ± 5.0 versus 22.6 seconds ± 7.6 for 80{\%} DCE, 0.052 ± 0.017 versus 0.086 ± 0.031 for SDNCE, and 0.47 HU/sec ± 0.70 versus 2.27 HU/sec ± 0.87 for slope (P < .001 for all indexes). Compared with the peak enhancement resulting from the constant-rate injection, that resulting from the exponentially decelerated injection was reduced by a mean of 17.2{\%} ± 10.0. CONCLUSION: Uniform vascular contrast enhancement and reduced contrast medium volume, which are desirable in CT angiography, can be achieved with exponentially decelerated injection.",
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N2 - PURPOSE: To investigate in computed tomographic (CT) angiography whether an exponentially decelerated contrast medium injection, as compared with a standard constant-rate injection, can facilitate uniform vascular contrast enhancement with a reduced contrast material volume. MATERIALS AND METHODS: CT angiography of the abdominal aorta was performed in 46 subjects by using an exponentially decelerated injection method: 134 mL of contrast medium was injected for 40 seconds, starting at 4.0 mL/sec and decreasing exponentially to 2.7 mL/sec by the end of the injection. Twenty-one of these subjects also underwent CT angiography with a constant-rate injection: 160 mL of contrast medium was injected for 40 seconds at a constant rate of 4 mL/sec. Time-enhancement curves and the magnitude of peak vascular enhancement were measured. Enhancement uniformity was evaluated by using three indexes: (a) duration of contrast enhancement achieved within 80% of the peak (80% DCE), (b) SD of the normalized contrast enhancement (SDNCE) measured from the beginning of spiral CT scanning to the time when the enhancement decreased to a level lower than the beginning level, and (c) slope of the enhancement curve calculated by using linear regression analysis. RESULTS: Exponentially decelerated injection resulted in more uniform enhancement. Mean values generated by using exponentially decelerated versus constant-rate injection in 21 paired comparisons were, respectively, 30.8 seconds ± 5.0 versus 22.6 seconds ± 7.6 for 80% DCE, 0.052 ± 0.017 versus 0.086 ± 0.031 for SDNCE, and 0.47 HU/sec ± 0.70 versus 2.27 HU/sec ± 0.87 for slope (P < .001 for all indexes). Compared with the peak enhancement resulting from the constant-rate injection, that resulting from the exponentially decelerated injection was reduced by a mean of 17.2% ± 10.0. CONCLUSION: Uniform vascular contrast enhancement and reduced contrast medium volume, which are desirable in CT angiography, can be achieved with exponentially decelerated injection.

AB - PURPOSE: To investigate in computed tomographic (CT) angiography whether an exponentially decelerated contrast medium injection, as compared with a standard constant-rate injection, can facilitate uniform vascular contrast enhancement with a reduced contrast material volume. MATERIALS AND METHODS: CT angiography of the abdominal aorta was performed in 46 subjects by using an exponentially decelerated injection method: 134 mL of contrast medium was injected for 40 seconds, starting at 4.0 mL/sec and decreasing exponentially to 2.7 mL/sec by the end of the injection. Twenty-one of these subjects also underwent CT angiography with a constant-rate injection: 160 mL of contrast medium was injected for 40 seconds at a constant rate of 4 mL/sec. Time-enhancement curves and the magnitude of peak vascular enhancement were measured. Enhancement uniformity was evaluated by using three indexes: (a) duration of contrast enhancement achieved within 80% of the peak (80% DCE), (b) SD of the normalized contrast enhancement (SDNCE) measured from the beginning of spiral CT scanning to the time when the enhancement decreased to a level lower than the beginning level, and (c) slope of the enhancement curve calculated by using linear regression analysis. RESULTS: Exponentially decelerated injection resulted in more uniform enhancement. Mean values generated by using exponentially decelerated versus constant-rate injection in 21 paired comparisons were, respectively, 30.8 seconds ± 5.0 versus 22.6 seconds ± 7.6 for 80% DCE, 0.052 ± 0.017 versus 0.086 ± 0.031 for SDNCE, and 0.47 HU/sec ± 0.70 versus 2.27 HU/sec ± 0.87 for slope (P < .001 for all indexes). Compared with the peak enhancement resulting from the constant-rate injection, that resulting from the exponentially decelerated injection was reduced by a mean of 17.2% ± 10.0. CONCLUSION: Uniform vascular contrast enhancement and reduced contrast medium volume, which are desirable in CT angiography, can be achieved with exponentially decelerated injection.

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KW - Computed tomography (CT), contrast media

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