Abstract
Introduction: The Frontotemporal Lobar Degeneration Module (FTLD-MOD) includes a neuropsychological battery designed to assess the clinical features of FTLD, although much is unknown about its utility. We investigated FTLD-MOD and Uniform Data Set 3.0 (UDS) language tests for differential diagnosis and disease monitoring. Methods: Linear regressions compared baseline performances in 1655 National Alzheimer’s Coordinating Center participants (behavioral variant frontotemporal dementia (bvFTD, n = 612), semantic variant primary progressive aphasia (svPPA, n = 185), non-fluent/agrammatic variant PPA (nfvPPA, n = 168), logopenic variant PPA (lvPPA, n = 109), and controls (n = 581)). Sample sizes to detect treatment effects were estimated using longitudinal data. Results: Among PPAs, the FTLD-MOD language tasks and UDS Multilingual Naming Test accurately discriminated svPPA. Number Span Forward best discriminated lvPPA; Phonemic:Semantic Fluency ratio was excellent for nfvPPA classification. UDS fluency and naming measures required the smallest sample size to detect meaningful change. Discussion: The FTLD-MOD and UDS differentiated among PPA subtypes. UDS 3.0 measures performed best for longitudinal monitoring.
Original language | English (US) |
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Article number | e12148 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 2021 |
Keywords
- Clinical trials
- Cognition
- Differential diagnosis
- Endpoints
- FTLD module
- Frontotemporal dementia (FTD)
- Longitudinal
- Neuropsychology
- Primary progressive aphasia (PPA)
- Speech
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health