Unexpected immunoglobulin light chain gene rearrangements in myeloid antigen positive acute lymphoid leukemia

Elisabeth Paietta, Brian Van Ness, John M. Bennett, Camille Pellone, Daniel D Billadeau, Peter A. Cassileth, Peter H. Wiernik

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Blast cells from 10 immunologically diagnosed adult acute lymphoid leukemias expressing myeloid antigens (M+ ALL) were studied for immunoglobulin heavy (IgH) and light chain as well as T-cell receptor (TCR)-β chain gene rearrangements. All but one leukemic isolate met the FAB criteria for ALL. DNA from 2 patients with pre-pre-B-ALL (CD10-) and 1 patient with common ALL contained rearranged Ig light chain (κ in two, λ in one case) in addition to rearranged IgH genes. The TCR-β chain gene was germline in all pre-pre-B leukemias and rearranged in common ALLs (bigenotypic features). One patient with mature B-ALL showed IgH and light chain gene rearrangements. DNA from 2 pre-T-ALLs contained rearranged TCR-β chain genes plus rearranged IgH genes in one case. Ig light chain gene rearrangements in immature M+ ALL were not associated with gross chromosomal abnormalities except for one Philadelphia chromosome positive case. The occurrence of Ig light chain gene rearrangements in M- ALL with immature lymphoid immunophenotype might represent an hitherto unrecognized aberrant differentiation potential of transformed multipotential stem cells with commitment towards the lymphoid lineage.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalLeukemia Research
Volume15
Issue number2-3
DOIs
StatePublished - 1991
Externally publishedYes

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Immunoglobulin Light Chain Genes
Gene Rearrangement
Precursor Cell Lymphoblastic Leukemia-Lymphoma
T-Cell Receptor Genes
Antigens
Immunoglobulin Genes
Light
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Immunoglobulin Heavy Chain Genes
Immunoglobulin Light Chains
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Philadelphia Chromosome
Immunoglobulin Heavy Chains
DNA
Chromosome Aberrations
Leukemia
Stem Cells

Keywords

  • Acute lymphoid leukemia
  • genotype
  • myeloid antigen

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Unexpected immunoglobulin light chain gene rearrangements in myeloid antigen positive acute lymphoid leukemia. / Paietta, Elisabeth; Van Ness, Brian; Bennett, John M.; Pellone, Camille; Billadeau, Daniel D; Cassileth, Peter A.; Wiernik, Peter H.

In: Leukemia Research, Vol. 15, No. 2-3, 1991, p. 149-155.

Research output: Contribution to journalArticle

Paietta, Elisabeth ; Van Ness, Brian ; Bennett, John M. ; Pellone, Camille ; Billadeau, Daniel D ; Cassileth, Peter A. ; Wiernik, Peter H. / Unexpected immunoglobulin light chain gene rearrangements in myeloid antigen positive acute lymphoid leukemia. In: Leukemia Research. 1991 ; Vol. 15, No. 2-3. pp. 149-155.
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