Understanding the key to targeting the IGF axis in cancer: A biomarker assessment

Kunal Lodhia, Piyawan Tienchaiananda, Paul Haluska

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this failed to translate to patient benefit in Phase 2/3 trails in unselected patients. This was further complicated by the toxicity, including hyperglycemia, which largely results from the overlap between IGF and insulin signaling systems and associated feedback mechanisms. This has halted the clinical development of inhibitors targeting IGF signaling, which has limited the availability of biopsy samples for correlative studies to understand biomarkers of response. Indeed, a major factor contributing to lack of clinical benefit of IGF targeting agents has been difficulty in identifying patients with tumors driven by IGF signaling due the lack of predictive biomarkers. In this review we will describe the IGF system, rationale for targeting IGF signaling, the potential liabilities of targeting strategies and potential biomarkers that may improve success.

Original languageEnglish (US)
Article number142
JournalFrontiers in Oncology
Volume5
Issue numberJUN
DOIs
StatePublished - 2015

Keywords

  • Biomarker discovery
  • Endocrine system diseases
  • IGF binding proteins
  • IGF system and signaling
  • Insulin receptor
  • Insulin receptor substrate proteins
  • Insulin-like growth factor receptor
  • Targeted therapies

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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