Understanding the immunology of Graves' ophthalmopathy: Is it an autoimmune disease?

R. S. Bahn

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The notion that Graves' ophthalmopathy is an autoimmune disease has been based primarily on the clinical associations between it and Graves' hyperthyroidism, and on the frequently beneficial response of the disease to immunosuppressive therapy. Recent advances in molecular biology have led to new insights into the pathogenesis that support an autoimmune basis for this condition. In particular, there is now compelling - although not definitive - evidence that, if verified, would represent disease transfer by thyroid- secreting hormone receptor-sensitized T cells. Future studies using animal models and in vitro systems will allow definitive identification of the immune cell types, autoantigens, and autoantibodies involved in the pathogenesis of Graves' ophthalmopathy.

Original languageEnglish (US)
Pages (from-to)287-296
Number of pages10
JournalEndocrinology and Metabolism Clinics of North America
Volume29
Issue number2
StatePublished - 2000

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Immunology
Graves Ophthalmopathy
Allergy and Immunology
Autoimmune Diseases
Thyroid Hormone Receptors
Autoantigens
Hyperthyroidism
Immunosuppressive Agents
Autoantibodies
Molecular Biology
Molecular biology
T-cells
Animal Models
T-Lymphocytes
Identification (control systems)
Animals
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Understanding the immunology of Graves' ophthalmopathy : Is it an autoimmune disease? / Bahn, R. S.

In: Endocrinology and Metabolism Clinics of North America, Vol. 29, No. 2, 2000, p. 287-296.

Research output: Contribution to journalArticle

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