TY - JOUR
T1 - Understanding the immunology of Graves' ophthalmopathy
T2 - Is it an autoimmune disease?
AU - Bahn, R. S.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - The notion that Graves' ophthalmopathy is an autoimmune disease has been based primarily on the clinical associations between it and Graves' hyperthyroidism, and on the frequently beneficial response of the disease to immunosuppressive therapy. Recent advances in molecular biology have led to new insights into the pathogenesis that support an autoimmune basis for this condition. In particular, there is now compelling - although not definitive - evidence that, if verified, would represent disease transfer by thyroid- secreting hormone receptor-sensitized T cells. Future studies using animal models and in vitro systems will allow definitive identification of the immune cell types, autoantigens, and autoantibodies involved in the pathogenesis of Graves' ophthalmopathy.
AB - The notion that Graves' ophthalmopathy is an autoimmune disease has been based primarily on the clinical associations between it and Graves' hyperthyroidism, and on the frequently beneficial response of the disease to immunosuppressive therapy. Recent advances in molecular biology have led to new insights into the pathogenesis that support an autoimmune basis for this condition. In particular, there is now compelling - although not definitive - evidence that, if verified, would represent disease transfer by thyroid- secreting hormone receptor-sensitized T cells. Future studies using animal models and in vitro systems will allow definitive identification of the immune cell types, autoantigens, and autoantibodies involved in the pathogenesis of Graves' ophthalmopathy.
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U2 - 10.1016/S0889-8529(05)70132-8
DO - 10.1016/S0889-8529(05)70132-8
M3 - Article
C2 - 10874530
AN - SCOPUS:0034082269
SN - 0889-8529
VL - 29
SP - 287
EP - 296
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 2
ER -