Understanding the immune response to seasonal influenza vaccination in older adults: A systems biology approach

Nathaniel D. Lambert, Inna G. Ovsyannikova, V. Shane Pankratz, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Annual vaccination against seasonal influenza is recommended to decrease disease-related mortality and morbidity. However, one population that responds suboptimally to influenza vaccine is adults over the age of 65 years. The natural aging process is associated with a complex deterioration of multiple components of the host immune system. Research into this phenomenon, known as immunosenescence, has shown that aging alters both the innate and adaptive branches of the immune system. The intricate mechanisms involved in immune response to influenza vaccine, and how these responses are altered with age, have led us to adopt a more encompassing systems biology approach to understand exactly why the response to vaccination diminishes with age. Here, the authors review what changes occur with immunosenescence, and some immunogenetic factors that influence response, and outline the systems biology approach to understand the immune response to seasonal influenza vaccination in older adults.

Original languageEnglish (US)
Pages (from-to)985-994
Number of pages10
JournalExpert Review of Vaccines
Volume11
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Systems Biology
Human Influenza
Vaccination
Influenza Vaccines
Immune System
Immunogenetics
Morbidity
Mortality
Research
Population
Immunosenescence

Keywords

  • bioinformatics
  • immunogenetics
  • immunosenescence
  • influenza
  • seasonal influenza vaccine
  • systems biology
  • vaccine-induced immunity
  • vaccinomics

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

Lambert, N. D., Ovsyannikova, I. G., Pankratz, V. S., Jacobson, R. M., & Poland, G. A. (2012). Understanding the immune response to seasonal influenza vaccination in older adults: A systems biology approach. Expert Review of Vaccines, 11(8), 985-994. https://doi.org/10.1586/erv.12.61

Understanding the immune response to seasonal influenza vaccination in older adults : A systems biology approach. / Lambert, Nathaniel D.; Ovsyannikova, Inna G.; Pankratz, V. Shane; Jacobson, Robert M.; Poland, Gregory A.

In: Expert Review of Vaccines, Vol. 11, No. 8, 08.2012, p. 985-994.

Research output: Contribution to journalArticle

Lambert, Nathaniel D. ; Ovsyannikova, Inna G. ; Pankratz, V. Shane ; Jacobson, Robert M. ; Poland, Gregory A. / Understanding the immune response to seasonal influenza vaccination in older adults : A systems biology approach. In: Expert Review of Vaccines. 2012 ; Vol. 11, No. 8. pp. 985-994.
@article{2b0b09b06ce5426ea89b8bed50dc5f46,
title = "Understanding the immune response to seasonal influenza vaccination in older adults: A systems biology approach",
abstract = "Annual vaccination against seasonal influenza is recommended to decrease disease-related mortality and morbidity. However, one population that responds suboptimally to influenza vaccine is adults over the age of 65 years. The natural aging process is associated with a complex deterioration of multiple components of the host immune system. Research into this phenomenon, known as immunosenescence, has shown that aging alters both the innate and adaptive branches of the immune system. The intricate mechanisms involved in immune response to influenza vaccine, and how these responses are altered with age, have led us to adopt a more encompassing systems biology approach to understand exactly why the response to vaccination diminishes with age. Here, the authors review what changes occur with immunosenescence, and some immunogenetic factors that influence response, and outline the systems biology approach to understand the immune response to seasonal influenza vaccination in older adults.",
keywords = "bioinformatics, immunogenetics, immunosenescence, influenza, seasonal influenza vaccine, systems biology, vaccine-induced immunity, vaccinomics",
author = "Lambert, {Nathaniel D.} and Ovsyannikova, {Inna G.} and Pankratz, {V. Shane} and Jacobson, {Robert M.} and Poland, {Gregory A.}",
year = "2012",
month = "8",
doi = "10.1586/erv.12.61",
language = "English (US)",
volume = "11",
pages = "985--994",
journal = "Expert Review of Vaccines",
issn = "1476-0584",
publisher = "Expert Reviews Ltd.",
number = "8",

}

TY - JOUR

T1 - Understanding the immune response to seasonal influenza vaccination in older adults

T2 - A systems biology approach

AU - Lambert, Nathaniel D.

AU - Ovsyannikova, Inna G.

AU - Pankratz, V. Shane

AU - Jacobson, Robert M.

AU - Poland, Gregory A.

PY - 2012/8

Y1 - 2012/8

N2 - Annual vaccination against seasonal influenza is recommended to decrease disease-related mortality and morbidity. However, one population that responds suboptimally to influenza vaccine is adults over the age of 65 years. The natural aging process is associated with a complex deterioration of multiple components of the host immune system. Research into this phenomenon, known as immunosenescence, has shown that aging alters both the innate and adaptive branches of the immune system. The intricate mechanisms involved in immune response to influenza vaccine, and how these responses are altered with age, have led us to adopt a more encompassing systems biology approach to understand exactly why the response to vaccination diminishes with age. Here, the authors review what changes occur with immunosenescence, and some immunogenetic factors that influence response, and outline the systems biology approach to understand the immune response to seasonal influenza vaccination in older adults.

AB - Annual vaccination against seasonal influenza is recommended to decrease disease-related mortality and morbidity. However, one population that responds suboptimally to influenza vaccine is adults over the age of 65 years. The natural aging process is associated with a complex deterioration of multiple components of the host immune system. Research into this phenomenon, known as immunosenescence, has shown that aging alters both the innate and adaptive branches of the immune system. The intricate mechanisms involved in immune response to influenza vaccine, and how these responses are altered with age, have led us to adopt a more encompassing systems biology approach to understand exactly why the response to vaccination diminishes with age. Here, the authors review what changes occur with immunosenescence, and some immunogenetic factors that influence response, and outline the systems biology approach to understand the immune response to seasonal influenza vaccination in older adults.

KW - bioinformatics

KW - immunogenetics

KW - immunosenescence

KW - influenza

KW - seasonal influenza vaccine

KW - systems biology

KW - vaccine-induced immunity

KW - vaccinomics

UR - http://www.scopus.com/inward/record.url?scp=84866726837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866726837&partnerID=8YFLogxK

U2 - 10.1586/erv.12.61

DO - 10.1586/erv.12.61

M3 - Article

C2 - 23002979

AN - SCOPUS:84866726837

VL - 11

SP - 985

EP - 994

JO - Expert Review of Vaccines

JF - Expert Review of Vaccines

SN - 1476-0584

IS - 8

ER -