Understanding scanner upgrade effects on brain integrity & connectivity measures

L. Zhan, N. Jahanshad, Y. Jin, T. M. Nir, C. D. Leonardo, Matthew A Bernstein, B. Borowski, Clifford R Jr. Jack, P. M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Large multi-site studies, such as the Alzheimer's disease Neuroimaging Initiative (ADNI) are designed to harmonize imaging protocols as far as possible across scanning sites. ADNI-2 collects diffusion-weighted images (DWI) at 14 sites, with a consistent scanner manufacturer (General Electric), magnetic field strength (3T) and consistent acquisition parameters - including voxel size and the number of gradient directions. Here we studied how the SNR, voxel-wise and ROI-based diffusion measures, and derived connectivity matrices and network properties depended on the scanner platform (with "HD" denoting version 16.x software and lower and DV being 20.x and higher). We found scanner platform effects on voxel-based FA, in several ROIs, but not on SNR or network properties. These results indicate the importance of accounting for any differences in scanner platform in multi-site DTI studies, even when the protocols are harmonized in all other respects.

Original languageEnglish (US)
Title of host publication2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages234-237
Number of pages4
ISBN (Print)9781467319591
StatePublished - Jul 29 2014
Event2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing
Duration: Apr 29 2014May 2 2014

Other

Other2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
CityBeijing
Period4/29/145/2/14

Keywords

  • Anisotropy
  • Brain network
  • Connectivity
  • Diffusion MRI
  • Scanner
  • SNR

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Zhan, L., Jahanshad, N., Jin, Y., Nir, T. M., Leonardo, C. D., Bernstein, M. A., Borowski, B., Jack, C. R. J., & Thompson, P. M. (2014). Understanding scanner upgrade effects on brain integrity & connectivity measures. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 234-237). [6867852] Institute of Electrical and Electronics Engineers Inc..