Understanding scanner upgrade effects on brain integrity & connectivity measures

L. Zhan; N. Jahanshad; Y. Jin; T. M. Nir; C. D. Leonardo; Matthew A Bernstein; B. Borowski; Clifford R Jr. Jack; P. M. Thompson

Understanding scanner upgrade effects on brain integrity & connectivity measures

L. Zhan, N. Jahanshad, Y. Jin, T. M. Nir, C. D. Leonardo, Matthew A Bernstein, B. Borowski, Clifford R Jr. Jack, P. M. Thompson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Large multi-site studies, such as the Alzheimer's disease Neuroimaging Initiative (ADNI) are designed to harmonize imaging protocols as far as possible across scanning sites. ADNI-2 collects diffusion-weighted images (DWI) at 14 sites, with a consistent scanner manufacturer (General Electric), magnetic field strength (3T) and consistent acquisition parameters - including voxel size and the number of gradient directions. Here we studied how the SNR, voxel-wise and ROI-based diffusion measures, and derived connectivity matrices and network properties depended on the scanner platform (with "HD" denoting version 16.x software and lower and DV being 20.x and higher). We found scanner platform effects on voxel-based FA, in several ROIs, but not on SNR or network properties. These results indicate the importance of accounting for any differences in scanner platform in multi-site DTI studies, even when the protocols are harmonized in all other respects.

Original language	English (US)
Title of host publication	2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	234-237
Number of pages	4
ISBN (Print)	9781467319591
State	Published - Jul 29 2014
Event	2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing Duration: Apr 29 2014 → May 2 2014

Other

Other	2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
City	Beijing
Period	4/29/14 → 5/2/14

Keywords

Anisotropy
Brain network
Connectivity
Diffusion MRI
Scanner
SNR

ASJC Scopus subject areas

Biomedical Engineering
Radiology Nuclear Medicine and imaging

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Zhan, L., Jahanshad, N., Jin, Y., Nir, T. M., Leonardo, C. D., Bernstein, M. A., Borowski, B., Jack, C. R. J., & Thompson, P. M. (2014). Understanding scanner upgrade effects on brain integrity & connectivity measures. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 234-237). [6867852] Institute of Electrical and Electronics Engineers Inc..

Understanding scanner upgrade effects on brain integrity & connectivity measures. / Zhan, L.; Jahanshad, N.; Jin, Y.; Nir, T. M.; Leonardo, C. D.; Bernstein, Matthew A; Borowski, B.; Jack, Clifford R Jr.; Thompson, P. M.

2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 234-237 6867852.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zhan, L, Jahanshad, N, Jin, Y, Nir, TM, Leonardo, CD, Bernstein, MA, Borowski, B, Jack, CRJ & Thompson, PM 2014, Understanding scanner upgrade effects on brain integrity & connectivity measures. in 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014., 6867852, Institute of Electrical and Electronics Engineers Inc., pp. 234-237, 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014, Beijing, 4/29/14.

Zhan, L. ; Jahanshad, N. ; Jin, Y. ; Nir, T. M. ; Leonardo, C. D. ; Bernstein, Matthew A ; Borowski, B. ; Jack, Clifford R Jr. ; Thompson, P. M. / Understanding scanner upgrade effects on brain integrity & connectivity measures. 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 234-237

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