Understanding immunosenescence to improve responses to vaccines

Jörg J. Goronzy, Cornelia M. Weyand

Research output: Contribution to journalReview articlepeer-review

342 Scopus citations

Abstract

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80-100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.

Original languageEnglish (US)
Pages (from-to)428-436
Number of pages9
JournalNature immunology
Volume14
Issue number5
DOIs
StatePublished - May 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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