Understanding cardiac sarcomere assembly with zebrafish genetics

Jingchun Yang, Yu huan Shih, Xiaolei Xu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Mutations in sarcomere genes have been found in many inheritable human diseases, including hypertrophic cardiomyopathy. Elucidating the molecular mechanisms of sarcomere assembly shall facilitate understanding of the pathogenesis of sarcomere-based cardiac disease. Recently, biochemical and genomic studies have identified many new genes encoding proteins that localize to the sarcomere. However, their precise functions in sarcomere assembly and sarcomere-based cardiac disease are unknown. Here, we review zebrafish as an emerging vertebrate model for these studies. We summarize the techniques offered by this animal model to manipulate genes of interest, annotate gene expression, and describe the resulting phenotypes. We survey the sarcomere genes that have been investigated in zebrafish and discuss the potential of applying this in vivo model for larger-scale genetic studies. Anat Rec, 297:1681-1693, 2014.

Original languageEnglish (US)
Pages (from-to)1681-1693
Number of pages13
JournalAnatomical Record
Volume297
Issue number9
DOIs
StatePublished - Sep 2014

Keywords

  • Cardiomyopathy
  • Genetics
  • Myofibrillogenesis
  • Sarcomere
  • Zebrafish

ASJC Scopus subject areas

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

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