Understanding adenomyosis: A case control study

F. Andrei Taran, Amy L. Weaver, Charles C. Coddington, Elizabeth A. Stewart

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objective: To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas. Design: Retrospective case-control study. Setting: Academic medical center. Patient(s): The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis. Intervention(s): Retrospective medical record review of hospital and ambulatory records. Main Outcome Measure(s): Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone. Result(s): Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing >150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas. Conclusion(s): Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.

Original languageEnglish (US)
Pages (from-to)1223-1228
Number of pages6
JournalFertility and Sterility
Volume94
Issue number4
DOIs
StatePublished - Sep 1 2010

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Keywords

  • Adenomyosis
  • depression
  • prolactin
  • uterine leiomyomas

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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