Abstract
Objective: To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas. Design: Retrospective case-control study. Setting: Academic medical center. Patient(s): The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis. Intervention(s): Retrospective medical record review of hospital and ambulatory records. Main Outcome Measure(s): Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone. Result(s): Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing >150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas. Conclusion(s): Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.
Original language | English (US) |
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Pages (from-to) | 1223-1228 |
Number of pages | 6 |
Journal | Fertility and sterility |
Volume | 94 |
Issue number | 4 |
DOIs | |
State | Published - Sep 2010 |
Keywords
- Adenomyosis
- depression
- prolactin
- uterine leiomyomas
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology