TY - JOUR
T1 - Understanding adenomyosis
T2 - A case control study
AU - Taran, F. Andrei
AU - Weaver, Amy L.
AU - Coddington, Charles C.
AU - Stewart, Elizabeth A.
PY - 2010/9
Y1 - 2010/9
N2 - Objective: To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas. Design: Retrospective case-control study. Setting: Academic medical center. Patient(s): The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis. Intervention(s): Retrospective medical record review of hospital and ambulatory records. Main Outcome Measure(s): Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone. Result(s): Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing >150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas. Conclusion(s): Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.
AB - Objective: To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas. Design: Retrospective case-control study. Setting: Academic medical center. Patient(s): The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis. Intervention(s): Retrospective medical record review of hospital and ambulatory records. Main Outcome Measure(s): Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone. Result(s): Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing >150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas. Conclusion(s): Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.
KW - Adenomyosis
KW - depression
KW - prolactin
KW - uterine leiomyomas
UR - http://www.scopus.com/inward/record.url?scp=77956184457&partnerID=8YFLogxK
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U2 - 10.1016/j.fertnstert.2009.06.049
DO - 10.1016/j.fertnstert.2009.06.049
M3 - Article
C2 - 19643403
AN - SCOPUS:77956184457
SN - 0015-0282
VL - 94
SP - 1223
EP - 1228
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -