Underestimation of liver-related mortality in the United States

Sumeet K. Asrani, Joseph J. Larson, Barbara Yawn, Terry M Therneau, W. Ray Kim

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Background & Aims According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12th leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver mortality in the United States. Methods Mortality data were obtained from the Rochester Epidemiology Project (1999-2008) and the National Death Registry (1979-2008). Liver-specific mortality values were calculated. In contrast to the narrow NCHS definition, updated liver-related causes of death included other specific liver diagnoses (eg, hepatorenal syndrome), viral hepatitis, and hepatobiliary cancers. Results The Rochester Epidemiology Project database contained information on 261 liver-related deaths, with an age- and sex-adjusted death rate of 27.0/100,000 persons (95% confidence interval: 23.7-30.3). Of these, only 71 deaths (27.2%) would have been captured by the NCHS definition. Of cases for which viral hepatitis or hepatobiliary cancer was the cause of death, 96.9% and 94.3% had liver-related immediate causes of death, respectively. In analysis of data from the National Death registry (2008), use of the updated definition increased liver mortality by >2-fold (from 11.7 to 25.7 deaths/100,000, respectively). Using NCHS definitions, liver-related deaths decreased from 18.9/100,000 in 1979 to 11.7/100,000 in 2008 - a reduction of 38%. However, using the updated estimate, liver-related deaths were essentially unchanged from 1979 (25.8/100,000) to 2008 (25.7/100,000). Mortality burden was systematically underestimated among non-whites and persons of Hispanic ethnicity. Conclusions Based on analyses of the Rochester Epidemiology Project and National Death databases, liver-related mortality has been underestimated during the past 2 decades in the United States.

Original languageEnglish (US)
JournalGastroenterology
Volume145
Issue number2
DOIs
StatePublished - Aug 2013

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Mortality
Liver
National Center for Health Statistics (U.S.)
Cause of Death
Epidemiology
Hepatitis
Registries
Liver Diseases
Databases
Hepatorenal Syndrome
Hispanic Americans
Liver Cirrhosis
Neoplasms
Chronic Disease
Confidence Intervals

Keywords

  • Hepatocellular Carcinoma Rate of Death HCV HBV Population

ASJC Scopus subject areas

  • Gastroenterology

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Underestimation of liver-related mortality in the United States. / Asrani, Sumeet K.; Larson, Joseph J.; Yawn, Barbara; Therneau, Terry M; Kim, W. Ray.

In: Gastroenterology, Vol. 145, No. 2, 08.2013.

Research output: Contribution to journalArticle

Asrani, Sumeet K. ; Larson, Joseph J. ; Yawn, Barbara ; Therneau, Terry M ; Kim, W. Ray. / Underestimation of liver-related mortality in the United States. In: Gastroenterology. 2013 ; Vol. 145, No. 2.
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abstract = "Background & Aims According to the National Center for Health Statistics (NCHS), chronic liver disease and cirrhosis is the 12th leading cause of death in the United States. However, this single descriptor might not adequately enumerate all deaths from liver disease. The aim of our study was to update data on liver mortality in the United States. Methods Mortality data were obtained from the Rochester Epidemiology Project (1999-2008) and the National Death Registry (1979-2008). Liver-specific mortality values were calculated. In contrast to the narrow NCHS definition, updated liver-related causes of death included other specific liver diagnoses (eg, hepatorenal syndrome), viral hepatitis, and hepatobiliary cancers. Results The Rochester Epidemiology Project database contained information on 261 liver-related deaths, with an age- and sex-adjusted death rate of 27.0/100,000 persons (95{\%} confidence interval: 23.7-30.3). Of these, only 71 deaths (27.2{\%}) would have been captured by the NCHS definition. Of cases for which viral hepatitis or hepatobiliary cancer was the cause of death, 96.9{\%} and 94.3{\%} had liver-related immediate causes of death, respectively. In analysis of data from the National Death registry (2008), use of the updated definition increased liver mortality by >2-fold (from 11.7 to 25.7 deaths/100,000, respectively). Using NCHS definitions, liver-related deaths decreased from 18.9/100,000 in 1979 to 11.7/100,000 in 2008 - a reduction of 38{\%}. However, using the updated estimate, liver-related deaths were essentially unchanged from 1979 (25.8/100,000) to 2008 (25.7/100,000). Mortality burden was systematically underestimated among non-whites and persons of Hispanic ethnicity. Conclusions Based on analyses of the Rochester Epidemiology Project and National Death databases, liver-related mortality has been underestimated during the past 2 decades in the United States.",
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