Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach

Angela Baker; Esteban Braggio; Susanna Jacobus; Sungwon Jung; Dirk Larson; Terry Therneau; Angela Dispenzieri; Scott A. Van Wier; Gregory Ahmann; Joan Levy; Louise Perkins; Seungchan Kim; Kimberly Henderson; David Vesole; S. Vincent Rajkumar; Diane F. Jelinek; John Carpten; Rafael Fonseca

doi:10.1182/blood-2012-07-443606

Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach

Angela Baker, Esteban Braggio, Susanna Jacobus, Sungwon Jung, Dirk Larson, Terry Therneau, Angela Dispenzieri, Scott A. Van Wier, Gregory Ahmann, Joan Levy, Louise Perkins, Seungchan Kim, Kimberly Henderson, David Vesole, S. Vincent Rajkumar, Diane F. Jelinek, John Carpten, Rafael Fonseca

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Epidemiological data have suggested that African American (AA) persons are twice as likely to be diagnosed with multiple myeloma (MM) compared with European American (EA) persons. Here, we have analyzed a set of cytogenetic and genomic data derived from AA and EA MM patients. We have compared the frequency of IgH translocations in a series of data from 115 AA patients from 3 studies and 353 EA patients from the Eastern Cooperative Oncology Group (ECOG) studies E4A03 and E9487. We have also interrogated tumors from 45 AA and 196 EA MM patients for somatic copy number abnormalities associated with poor outcome. In addition, 35 AA and 178 EA patients were investigated for a transcriptional profile associated with high-risk disease. Overall, based on this cohort, genetic profiles were similar except for a significantly lower frequency of IgH translocations (40% vs 52%; P 5 .032) in AA patients. Frequency differences of somatic copy number aberrations were not significant after correction for multiple testing. There was also no significant difference in the frequency of high-risk disease based on gene expression profiling. Our study represents the first comprehensive comparisons of the frequency and distribution of molecular alterations in MM tumors between AA and EA patients.

Original language	English (US)
Pages (from-to)	3147-3152
Number of pages	6
Journal	Blood
Volume	121
Issue number	16
DOIs	https://doi.org/10.1182/blood-2012-07-443606
State	Published - 2013

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood-2012-07-443606

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Baker, A., Braggio, E., Jacobus, S., Jung, S., Larson, D., Therneau, T., Dispenzieri, A., Van Wier, S. A., Ahmann, G., Levy, J., Perkins, L., Kim, S., Henderson, K., Vesole, D., Vincent Rajkumar, S., Jelinek, D. F., Carpten, J., & Fonseca, R. (2013). Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach. Blood, 121(16), 3147-3152. https://doi.org/10.1182/blood-2012-07-443606

Baker, A, Braggio, E, Jacobus, S, Jung, S, Larson, D, Therneau, T , Dispenzieri, A, Van Wier, SA, Ahmann, G, Levy, J, Perkins, L, Kim, S, Henderson, K, Vesole, D, Vincent Rajkumar, S , Jelinek, DF, Carpten, J & Fonseca, R 2013, 'Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach', Blood, vol. 121, no. 16, pp. 3147-3152. https://doi.org/10.1182/blood-2012-07-443606

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title = "Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach",

abstract = "Epidemiological data have suggested that African American (AA) persons are twice as likely to be diagnosed with multiple myeloma (MM) compared with European American (EA) persons. Here, we have analyzed a set of cytogenetic and genomic data derived from AA and EA MM patients. We have compared the frequency of IgH translocations in a series of data from 115 AA patients from 3 studies and 353 EA patients from the Eastern Cooperative Oncology Group (ECOG) studies E4A03 and E9487. We have also interrogated tumors from 45 AA and 196 EA MM patients for somatic copy number abnormalities associated with poor outcome. In addition, 35 AA and 178 EA patients were investigated for a transcriptional profile associated with high-risk disease. Overall, based on this cohort, genetic profiles were similar except for a significantly lower frequency of IgH translocations (40% vs 52%; P 5 .032) in AA patients. Frequency differences of somatic copy number aberrations were not significant after correction for multiple testing. There was also no significant difference in the frequency of high-risk disease based on gene expression profiling. Our study represents the first comprehensive comparisons of the frequency and distribution of molecular alterations in MM tumors between AA and EA patients.",

author = "Angela Baker and Esteban Braggio and Susanna Jacobus and Sungwon Jung and Dirk Larson and Terry Therneau and Angela Dispenzieri and {Van Wier}, {Scott A.} and Gregory Ahmann and Joan Levy and Louise Perkins and Seungchan Kim and Kimberly Henderson and David Vesole and {Vincent Rajkumar}, S. and Jelinek, {Diane F.} and John Carpten and Rafael Fonseca",

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doi = "10.1182/blood-2012-07-443606",

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AU - Baker, Angela

AU - Braggio, Esteban

AU - Jacobus, Susanna

AU - Jung, Sungwon

AU - Larson, Dirk

AU - Therneau, Terry

AU - Dispenzieri, Angela

AU - Van Wier, Scott A.

AU - Ahmann, Gregory

AU - Levy, Joan

AU - Perkins, Louise

AU - Kim, Seungchan

AU - Henderson, Kimberly

AU - Vesole, David

AU - Vincent Rajkumar, S.

AU - Jelinek, Diane F.

AU - Carpten, John

AU - Fonseca, Rafael

PY - 2013

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N2 - Epidemiological data have suggested that African American (AA) persons are twice as likely to be diagnosed with multiple myeloma (MM) compared with European American (EA) persons. Here, we have analyzed a set of cytogenetic and genomic data derived from AA and EA MM patients. We have compared the frequency of IgH translocations in a series of data from 115 AA patients from 3 studies and 353 EA patients from the Eastern Cooperative Oncology Group (ECOG) studies E4A03 and E9487. We have also interrogated tumors from 45 AA and 196 EA MM patients for somatic copy number abnormalities associated with poor outcome. In addition, 35 AA and 178 EA patients were investigated for a transcriptional profile associated with high-risk disease. Overall, based on this cohort, genetic profiles were similar except for a significantly lower frequency of IgH translocations (40% vs 52%; P 5 .032) in AA patients. Frequency differences of somatic copy number aberrations were not significant after correction for multiple testing. There was also no significant difference in the frequency of high-risk disease based on gene expression profiling. Our study represents the first comprehensive comparisons of the frequency and distribution of molecular alterations in MM tumors between AA and EA patients.

AB - Epidemiological data have suggested that African American (AA) persons are twice as likely to be diagnosed with multiple myeloma (MM) compared with European American (EA) persons. Here, we have analyzed a set of cytogenetic and genomic data derived from AA and EA MM patients. We have compared the frequency of IgH translocations in a series of data from 115 AA patients from 3 studies and 353 EA patients from the Eastern Cooperative Oncology Group (ECOG) studies E4A03 and E9487. We have also interrogated tumors from 45 AA and 196 EA MM patients for somatic copy number abnormalities associated with poor outcome. In addition, 35 AA and 178 EA patients were investigated for a transcriptional profile associated with high-risk disease. Overall, based on this cohort, genetic profiles were similar except for a significantly lower frequency of IgH translocations (40% vs 52%; P 5 .032) in AA patients. Frequency differences of somatic copy number aberrations were not significant after correction for multiple testing. There was also no significant difference in the frequency of high-risk disease based on gene expression profiling. Our study represents the first comprehensive comparisons of the frequency and distribution of molecular alterations in MM tumors between AA and EA patients.

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Uncovering the biology of multiple myeloma among African Americans: A comprehensive genomics approach

Abstract

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