Uncommon inflammatory/immune-related myelopathies

Cristina Valencia-Sanchez; Eoin P. Flanagan

doi:10.1016/j.jneuroim.2021.577750

Uncommon inflammatory/immune-related myelopathies

Cristina Valencia-Sanchez, Eoin P. Flanagan

Neurology

Research output: Contribution to journal › Review article › peer-review

Abstract

The differential diagnosis for immune-mediated myelopathies is broad. Although clinical manifestations overlap, certain presentations are suggestive of a particular myelopathy etiology. Spine MRI lesion characteristics including the length and location, and the pattern of gadolinium enhancement, help narrow the differential diagnosis and exclude an extrinsic compressive cause. The discovery of specific antibodies that serve as biomarkers of myelitis such as aquaporin-4-IgG and myelin-oligodendrocyte -glycoprotein-IgG (MOG-IgG), has improved our understanding of myelitis pathophysiology and facilitated diagnosis. In this review we will focus on the pathophysiology, clinical presentation, imaging findings and treatment and outcomes of uncommon immune-mediated myelopathies.

Original language	English (US)
Article number	577750
Journal	Journal of neuroimmunology
Volume	361
DOIs	https://doi.org/10.1016/j.jneuroim.2021.577750
State	Published - Dec 15 2021

Keywords

Aquaporin 4
Autoimmune glial fibrillary acidic protein astrocytopathy
Myelin oligodendrocyte glycoprotein antibody-associated disease
Neuromyelitis optica spectrum disorders
Paraneoplastic myelopathy
Spinal cord sarcoidosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2021.577750

Cite this

@article{b27a3c5125024a33bcccc45c84d829af,

title = "Uncommon inflammatory/immune-related myelopathies",

abstract = "The differential diagnosis for immune-mediated myelopathies is broad. Although clinical manifestations overlap, certain presentations are suggestive of a particular myelopathy etiology. Spine MRI lesion characteristics including the length and location, and the pattern of gadolinium enhancement, help narrow the differential diagnosis and exclude an extrinsic compressive cause. The discovery of specific antibodies that serve as biomarkers of myelitis such as aquaporin-4-IgG and myelin-oligodendrocyte -glycoprotein-IgG (MOG-IgG), has improved our understanding of myelitis pathophysiology and facilitated diagnosis. In this review we will focus on the pathophysiology, clinical presentation, imaging findings and treatment and outcomes of uncommon immune-mediated myelopathies.",

keywords = "Aquaporin 4, Autoimmune glial fibrillary acidic protein astrocytopathy, Myelin oligodendrocyte glycoprotein antibody-associated disease, Neuromyelitis optica spectrum disorders, Paraneoplastic myelopathy, Spinal cord sarcoidosis",

author = "Cristina Valencia-Sanchez and Flanagan, {Eoin P.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2021.577750",

language = "English (US)",

volume = "361",

journal = "Journal of neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Uncommon inflammatory/immune-related myelopathies

AU - Valencia-Sanchez, Cristina

AU - Flanagan, Eoin P.

PY - 2021/12/15

Y1 - 2021/12/15

N2 - The differential diagnosis for immune-mediated myelopathies is broad. Although clinical manifestations overlap, certain presentations are suggestive of a particular myelopathy etiology. Spine MRI lesion characteristics including the length and location, and the pattern of gadolinium enhancement, help narrow the differential diagnosis and exclude an extrinsic compressive cause. The discovery of specific antibodies that serve as biomarkers of myelitis such as aquaporin-4-IgG and myelin-oligodendrocyte -glycoprotein-IgG (MOG-IgG), has improved our understanding of myelitis pathophysiology and facilitated diagnosis. In this review we will focus on the pathophysiology, clinical presentation, imaging findings and treatment and outcomes of uncommon immune-mediated myelopathies.

AB - The differential diagnosis for immune-mediated myelopathies is broad. Although clinical manifestations overlap, certain presentations are suggestive of a particular myelopathy etiology. Spine MRI lesion characteristics including the length and location, and the pattern of gadolinium enhancement, help narrow the differential diagnosis and exclude an extrinsic compressive cause. The discovery of specific antibodies that serve as biomarkers of myelitis such as aquaporin-4-IgG and myelin-oligodendrocyte -glycoprotein-IgG (MOG-IgG), has improved our understanding of myelitis pathophysiology and facilitated diagnosis. In this review we will focus on the pathophysiology, clinical presentation, imaging findings and treatment and outcomes of uncommon immune-mediated myelopathies.

KW - Aquaporin 4

KW - Autoimmune glial fibrillary acidic protein astrocytopathy

KW - Myelin oligodendrocyte glycoprotein antibody-associated disease

KW - Neuromyelitis optica spectrum disorders

KW - Paraneoplastic myelopathy

KW - Spinal cord sarcoidosis

UR - http://www.scopus.com/inward/record.url?scp=85117782139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85117782139&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2021.577750

DO - 10.1016/j.jneuroim.2021.577750

M3 - Review article

C2 - 34715593

AN - SCOPUS:85117782139

SN - 0165-5728

VL - 361

JO - Journal of neuroimmunology

JF - Journal of neuroimmunology

M1 - 577750

ER -

Uncommon inflammatory/immune-related myelopathies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this