Unawareness of Hyposmia in Elderly People With and Without Parkinson's Disease

Holly A. Shill, Joseph G. Hentz, John Nathaniel Caviness, Erika M Driver-Dunckley, Sandra Jacobson, Christine Belden, Marwan N. Sabbagh, Thomas G. Beach, Charles Howard Adler

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Hyposmia is common in Parkinson's disease (PD) and is also observed with normal aging. It can be ascertained through objective testing, but it is unclear whether patients are aware of deficits and whether this has implications for cognitive status. Methods: Subjects in the Arizona Study of Aging and Neurodegenerative Disorders were studied with annual motor and cognitive testing with objective smell testing (University of Pennsylvania Smell Identification Test; UPSIT) done every third year beginning in 2002. Those with a baseline UPSIT <25th percentile (hyposmia) were studied for presence of unawareness of hyposmia and cognitive status. Results: There were 75 subjects with PD and 143 nonparkinsonian controls with hyposmia. Lack of awareness of hyposmia was present in 16% of PD subjects and 47% of those without PD. In PD, there was no increase in unawareness in PD with dementia. In non-PD controls, unawareness was correlated with presence of dementia. Unawareness of hyposmia correlated most strongly with the neuropsychiatric tests of learning and memory. In controls without dementia or PD, 48% were unaware. Conclusions: Querying patients about anosmia might be useful in parkinsonian disorders without objective testing. However, in elderly controls, it should be followed by objective testing and lack of awareness has implications for worsened cognitive status.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalMovement Disorders Clinical Practice
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2016

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Parkinson Disease
Dementia
Smell
Olfaction Disorders
Parkinsonian Disorders
Neurodegenerative Diseases
Learning

Keywords

  • Alzheimer's
  • Biomarker
  • Olfaction
  • Parkinson's disease
  • Screening

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Unawareness of Hyposmia in Elderly People With and Without Parkinson's Disease. / Shill, Holly A.; Hentz, Joseph G.; Caviness, John Nathaniel; Driver-Dunckley, Erika M; Jacobson, Sandra; Belden, Christine; Sabbagh, Marwan N.; Beach, Thomas G.; Adler, Charles Howard.

In: Movement Disorders Clinical Practice, Vol. 3, No. 1, 01.01.2016, p. 43-47.

Research output: Contribution to journalArticle

Shill, Holly A. ; Hentz, Joseph G. ; Caviness, John Nathaniel ; Driver-Dunckley, Erika M ; Jacobson, Sandra ; Belden, Christine ; Sabbagh, Marwan N. ; Beach, Thomas G. ; Adler, Charles Howard. / Unawareness of Hyposmia in Elderly People With and Without Parkinson's Disease. In: Movement Disorders Clinical Practice. 2016 ; Vol. 3, No. 1. pp. 43-47.
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