Ultraviolet laser-induced fluorescence of colonic polyps

Kevin T. Schomacker, Joan K. Frisoli, Carolyn C. Compton, Thomas J Flotte, James M. Richter, Thomas F. Deutsch, Norman S. Nishioka

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Ultraviolet laser-induced fluorescence was examined in vivo to determine whether the technique can reliably distinguish between hyperplastic and adenomatous polyps of the colon. Spectra from 86 normal colonic sites, 35 hyperplastic polyps, and 49 adenomatous polyps were recorded in vivo. Polyp type was independently determined by two senior pathologists who were unaware of the fluorescence measurement. A multivariate linear regression analysis was used to differentiate spectra from hyperplastic and adenomatous polyps and resulted in a sensitivity, specificity, predictive value positive, and predictive value negative for identifying adenomatous polyps of 86%, 80%, 86%, and 80%, respectively. These values were not significantly different from the accuracy of routine clinical pathology. Thus, ultraviolet laser-induced fluorescence appears to show promise as a means for distinguishing tissue types. However, further experience is needed before its routine clinical use can be recommended. Significant changes in the fluorescence spectra occurred postmortem, suggesting that future studies of laser-induced fluorescence of colonic tissue must use data acquired in vivo.

Original languageEnglish (US)
Pages (from-to)1155-1160
Number of pages6
JournalGastroenterology
Volume102
Issue number4 PART 1
StatePublished - 1992
Externally publishedYes

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Colonic Polyps
Adenomatous Polyps
Lasers
Fluorescence
Polyps
Clinical Pathology
Linear Models
Colon
Regression Analysis
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Schomacker, K. T., Frisoli, J. K., Compton, C. C., Flotte, T. J., Richter, J. M., Deutsch, T. F., & Nishioka, N. S. (1992). Ultraviolet laser-induced fluorescence of colonic polyps. Gastroenterology, 102(4 PART 1), 1155-1160.

Ultraviolet laser-induced fluorescence of colonic polyps. / Schomacker, Kevin T.; Frisoli, Joan K.; Compton, Carolyn C.; Flotte, Thomas J; Richter, James M.; Deutsch, Thomas F.; Nishioka, Norman S.

In: Gastroenterology, Vol. 102, No. 4 PART 1, 1992, p. 1155-1160.

Research output: Contribution to journalArticle

Schomacker, KT, Frisoli, JK, Compton, CC, Flotte, TJ, Richter, JM, Deutsch, TF & Nishioka, NS 1992, 'Ultraviolet laser-induced fluorescence of colonic polyps', Gastroenterology, vol. 102, no. 4 PART 1, pp. 1155-1160.
Schomacker KT, Frisoli JK, Compton CC, Flotte TJ, Richter JM, Deutsch TF et al. Ultraviolet laser-induced fluorescence of colonic polyps. Gastroenterology. 1992;102(4 PART 1):1155-1160.
Schomacker, Kevin T. ; Frisoli, Joan K. ; Compton, Carolyn C. ; Flotte, Thomas J ; Richter, James M. ; Deutsch, Thomas F. ; Nishioka, Norman S. / Ultraviolet laser-induced fluorescence of colonic polyps. In: Gastroenterology. 1992 ; Vol. 102, No. 4 PART 1. pp. 1155-1160.
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AU - Deutsch, Thomas F.

AU - Nishioka, Norman S.

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