Abstract
In this work, a novel ultrasound-guided remote measurement technique is proposed for bone quality assessment. The technique utilizes an acoustic radiation force (ARF) excitation source to generate vibrational waves from the bone, and the ensuing radiating acoustic pressure is captured for analysis. Of particular interest, are extracting acoustic features related to the bone mechanical properties. Ex-vivo experiments of demineralized and intact (non-demineralized) bones are conducted, in order to determine the best acoustic features delineating the effects of demineralization. Mechanical tests demonstrate a reduction in the bone elastic modulus with demineralization. The acoustic waves from the intact bones travel faster than the demineralized bones. The spectra of the acoustic response of the demineralized bones exhibit higher attenuation for frequencies below 200 kHz in comparison to the intact bones. A time-frequency analysis exhibits a frequency shift with demineralization. Acoustic features related to these observations are extracted from the acoustic response of the bare bone experiments. Thereafter, attempts are made to recover these features from bone phantom experiments with overlaying tissue-like material. The results are summarized and discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | 2015 IEEE International Ultrasonics Symposium, IUS 2015 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Print) | 9781479981823 |
| DOIs | |
| State | Published - Nov 13 2015 |
| Event | IEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China Duration: Oct 21 2015 → Oct 24 2015 |
Other
| Other | IEEE International Ultrasonics Symposium, IUS 2015 |
|---|---|
| Country | Taiwan, Province of China |
| City | Taipei |
| Period | 10/21/15 → 10/24/15 |
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Keywords
- Bone Mineral Density
- Osteopenia Screening
- Ultrasound
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Ultrasound radiation force noninvasive bone assessment. / Wan, Leighton; Cheong, Mathew; Denis, Max; Fatemi, Mostafa; Alizad, Azra.
2015 IEEE International Ultrasonics Symposium, IUS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7329616.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Ultrasound radiation force noninvasive bone assessment
AU - Wan, Leighton
AU - Cheong, Mathew
AU - Denis, Max
AU - Fatemi, Mostafa
AU - Alizad, Azra
PY - 2015/11/13
Y1 - 2015/11/13
N2 - In this work, a novel ultrasound-guided remote measurement technique is proposed for bone quality assessment. The technique utilizes an acoustic radiation force (ARF) excitation source to generate vibrational waves from the bone, and the ensuing radiating acoustic pressure is captured for analysis. Of particular interest, are extracting acoustic features related to the bone mechanical properties. Ex-vivo experiments of demineralized and intact (non-demineralized) bones are conducted, in order to determine the best acoustic features delineating the effects of demineralization. Mechanical tests demonstrate a reduction in the bone elastic modulus with demineralization. The acoustic waves from the intact bones travel faster than the demineralized bones. The spectra of the acoustic response of the demineralized bones exhibit higher attenuation for frequencies below 200 kHz in comparison to the intact bones. A time-frequency analysis exhibits a frequency shift with demineralization. Acoustic features related to these observations are extracted from the acoustic response of the bare bone experiments. Thereafter, attempts are made to recover these features from bone phantom experiments with overlaying tissue-like material. The results are summarized and discussed.
AB - In this work, a novel ultrasound-guided remote measurement technique is proposed for bone quality assessment. The technique utilizes an acoustic radiation force (ARF) excitation source to generate vibrational waves from the bone, and the ensuing radiating acoustic pressure is captured for analysis. Of particular interest, are extracting acoustic features related to the bone mechanical properties. Ex-vivo experiments of demineralized and intact (non-demineralized) bones are conducted, in order to determine the best acoustic features delineating the effects of demineralization. Mechanical tests demonstrate a reduction in the bone elastic modulus with demineralization. The acoustic waves from the intact bones travel faster than the demineralized bones. The spectra of the acoustic response of the demineralized bones exhibit higher attenuation for frequencies below 200 kHz in comparison to the intact bones. A time-frequency analysis exhibits a frequency shift with demineralization. Acoustic features related to these observations are extracted from the acoustic response of the bare bone experiments. Thereafter, attempts are made to recover these features from bone phantom experiments with overlaying tissue-like material. The results are summarized and discussed.
KW - Bone Mineral Density
KW - Osteopenia Screening
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84962022175&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962022175&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2015.0509
DO - 10.1109/ULTSYM.2015.0509
M3 - Conference contribution
SN - 9781479981823
BT - 2015 IEEE International Ultrasonics Symposium, IUS 2015
PB - Institute of Electrical and Electronics Engineers Inc.
ER -