Ultrasound guided percutaneous common carotid artery access in piglets for intracoronary stem cell infusion

for the Wanek Program Preclinical Pipeline

Research output: Contribution to journalArticle

Abstract

In pigs, the deep location of the common carotid artery and overlying sternomastoideus muscle in the neck has led to the recommendation for a surgical cutdown for common carotid access, as opposed to minimally invasive techniques for vascular access. We sought to determine if direct percutaneous common carotid artery access in piglets is attainable. Seventeen piglets were anesthetized and intubated. Under two-dimensional and color flow Doppler ultrasound guidance, a 21 gauge needle was utilized to access the right common carotid artery. Following arterial puncture, the Seldinger technique was applied to place a 4 or 5 French introducer. Upon completion of cardiac catheterization with intracoronary stem cell infusion the introducer was removed and manual pressure was applied to prevent hematoma development. Successful access with an introducer was achieved in all 17 piglets. The average weight was 8.5 ± 1.7 kg. One piglet developed a hematoma with hemorrhaging from the catheterization site and was euthanized. This piglet was given bivalirudin for the procedure. After this incident, subsequent piglets were not given anticoagulation and no other complications occurred. Ultrasound guided percutaneous common carotid artery access in piglets is attainable in a safe, reliable, and reproducible manner when performed by microvascular experts.

Original languageEnglish (US)
Pages (from-to)88-92
Number of pages5
JournalLaboratory Animals
Volume52
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

carotid arteries
Common Carotid Artery
stem cells
piglets
Stem Cells
Hematoma
hematoma
Neck Muscles
Doppler Ultrasonography
catheters
Cardiac Catheterization
Punctures
Catheterization
Needles
Blood Vessels
right of access
Swine
Color
Pressure
Weights and Measures

Keywords

  • cardiac catheterization
  • carotid arteries
  • interventional
  • swine
  • ultrasonography

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Ultrasound guided percutaneous common carotid artery access in piglets for intracoronary stem cell infusion. / for the Wanek Program Preclinical Pipeline.

In: Laboratory Animals, Vol. 52, No. 1, 01.02.2018, p. 88-92.

Research output: Contribution to journalArticle

for the Wanek Program Preclinical Pipeline. / Ultrasound guided percutaneous common carotid artery access in piglets for intracoronary stem cell infusion. In: Laboratory Animals. 2018 ; Vol. 52, No. 1. pp. 88-92.
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