Ultrasound bladder vibrometry method for measuring viscoelasticity of the bladder wall

Ivan Z. Nenadic, Bo Qiang, Matthew W Urban, Luiz Henrique De Araujo Vasconcelo, Alireza Nabavizadeh, Azra Alizad, James F Greenleaf, Mostafa Fatemi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Increase in bladder stiffness could be associated with various pathophysiologic conditions. Measuring bladder viscoelasticity could be an important step towards understanding various disease processes and improving patient care. Here, we introduce ultrasound bladder vibrometry (UBV), a novel method for rapid and noninvasive measurement of bladder wall viscoelasticity. UBV uses acoustic radiation force to excite mechanical waves in the bladder wall and track the motion using ultrasound pulse-echo techniques. Fourier domain analysis of the tissue motion versus time is used to calculate the phase velocity dispersion (change of phase velocity as a function of frequency). The measured phase velocity dispersion is fit with the antisymmetric Lamb wave model to estimate tissue elasticity and viscosity. We used finite element analysis of viscoelastic plate deformation to investigate the effect of curvature on Lamb wave dispersion and showed that the effects of curvature are negligible. The feasibility of the UBV technique was demonstrated in ex vivo and in vivo settings. Elasticity and viscosity of excised pig at various filling volumes (V) and pressures (p) were found to be μ1 = 9.6 kPa and μ2 = 0.2 Pa s (V = 187 ml and p = 8.6 mmHg), μ1 = 48.7 kPa and μ2 = 3.5 Pa s (V = 267 ml and p = 17.6 mmHg), and μ1 = 106.9 kPa and μ2 = 1.5 Pa s (V = 327 ml and p = 27.6 mmHg) respectively. Transabdominal measurements in an anesthetized pig found values of bladder elasticity μ1 = 26.1 kPa and viscosity μ2 = 0.9 Pa s and demonstrate the ability of UBV to perform in vivo measurements. The results presented in this paper introduce a novel technique for measuring mechanical properties of the bladder and lay the foundation for further investigation of the effects of pathology on bladder viscoelasticity.

Original languageEnglish (US)
Pages (from-to)2675-2695
Number of pages21
JournalPhysics in Medicine and Biology
Volume58
Issue number8
DOIs
StatePublished - Apr 21 2013

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Urinary Bladder
Elasticity
Viscosity
Swine
Finite Element Analysis
Fourier Analysis
Acoustics
Patient Care
Radiation
Pathology
Pressure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ultrasound bladder vibrometry method for measuring viscoelasticity of the bladder wall. / Nenadic, Ivan Z.; Qiang, Bo; Urban, Matthew W; De Araujo Vasconcelo, Luiz Henrique; Nabavizadeh, Alireza; Alizad, Azra; Greenleaf, James F; Fatemi, Mostafa.

In: Physics in Medicine and Biology, Vol. 58, No. 8, 21.04.2013, p. 2675-2695.

Research output: Contribution to journalArticle

Nenadic, Ivan Z. ; Qiang, Bo ; Urban, Matthew W ; De Araujo Vasconcelo, Luiz Henrique ; Nabavizadeh, Alireza ; Alizad, Azra ; Greenleaf, James F ; Fatemi, Mostafa. / Ultrasound bladder vibrometry method for measuring viscoelasticity of the bladder wall. In: Physics in Medicine and Biology. 2013 ; Vol. 58, No. 8. pp. 2675-2695.
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