Ubiquitinated eosinophilic granules in the inferior olivary nucleus

S. Kato, A. Hirano, T. Suenaga, S. H. Yen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Ubiquitinated intracytoplasmic eosinophilic granules were found in the inferior olivary neurons of 99 normal individuals. The granules, ranging from 1 to 8 μm in diameter, were round and appeared in groups. Their number increased significantly with ageing. The frequency of the granules in 12 patients with Alzheimer's disease or spinocerebellar degeneration did not differ from that in normal subjects. The ubiquitinated eosinophilic granules can be considered to represent age-related changes in the inferior olivary neurons.

Original languageEnglish (US)
Pages (from-to)135-139
Number of pages5
JournalNeuropathology and Applied Neurobiology
Issue number2
StatePublished - 1990
Externally publishedYes


  • Ageing
  • Alzheimer's Disease
  • Eosinophilic granules
  • Inferior olive
  • Phosphorylated neurofilament
  • Spinocerebellar degeneration
  • Tau protein
  • Ubiquitin

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)


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