Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Jia Yu; Bo Qin; Zhenkun Lou

doi:10.1186/s13578-020-0380-1

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Jia Yu, Bo Qin, Zhenkun Lou

Oncology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.

Original language	English (US)
Article number	13
Journal	Cell and Bioscience
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13578-020-0380-1
State	Published - Feb 11 2020

Keywords

DNA damage
DNA repair
Double strand break
Ubiquitin
Ubiquitin-like protein

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1186/s13578-020-0380-1

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abstract = "Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.",

keywords = "DNA damage, DNA repair, Double strand break, Ubiquitin, Ubiquitin-like protein",

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AU - Qin, Bo

AU - Lou, Zhenkun

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.

AB - Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.

KW - DNA damage

KW - DNA repair

KW - Double strand break

KW - Ubiquitin

KW - Ubiquitin-like protein

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JO - Cell and Bioscience

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IS - 1

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ER -

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Abstract

Keywords

ASJC Scopus subject areas

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