Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Jia Yu, Bo Qin, Zhenkun Lou

Research output: Contribution to journalReview article

Abstract

Both environmental and endogenous factors induce various forms of DNA damage. DNA double strand break (DSB) is the most deleterious DNA lesion. The swift initiation of a complexed network of interconnected pathways to repair the DNA lesion is essential for cell survival. In the past years, the roles of ubiquitin and ubiquitin-like proteins in DNA damage response and DNA repair has been explored. These findings help us better understand the complicated mechanism of DSB signaling pathways.

Original languageEnglish (US)
Article number13
JournalCell and Bioscience
Volume10
Issue number1
DOIs
StatePublished - Feb 11 2020

Keywords

  • DNA damage
  • DNA repair
  • Double strand break
  • Ubiquitin
  • Ubiquitin-like protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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