Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kiran Kurmi, Sadae Hitosugi, Jia Yu, Felix Boakye-Agyeman, Elizabeth K. Wiese, Thomas R. Larson, Qing Dai, Yuichi Machida, Zhenkun Lou, Liewei M Wang, Judy C Boughey, Scott H Kaufmann, Matthew Philip Goetz, Larry M Karnitz, Taro D Hitosugi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Kurmi et al. report that the phosphocreatine (PCr) energy shuttle is important for breast tumor metabolism and growth. This energy shuttle is activated through MtCK1 Y153 phosphorylation by the HER2/ABL signaling axis. Using a creatine analog cyclocreatine that inhibits the PCr energy shuttle, they demonstrate reduced growth of trastuzumab-resistant breast tumors in mice.

Original languageEnglish (US)
Pages (from-to)833-847.e8
JournalCell Metabolism
Volume28
Issue number6
DOIs
StatePublished - Dec 4 2018

Fingerprint

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
Creatine
Growth
Neoplasms

Keywords

  • ABL kinase
  • breast cancer
  • cyclocreatine
  • HER2 tyrosine kinase
  • mitochondria
  • mitochondrial bioenergetics
  • mitochondrial creatine kinase
  • oncogenic tyrosine kinase
  • phosphocreatine
  • tyrosine phosphorylation

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway. / Kurmi, Kiran; Hitosugi, Sadae; Yu, Jia; Boakye-Agyeman, Felix; Wiese, Elizabeth K.; Larson, Thomas R.; Dai, Qing; Machida, Yuichi; Lou, Zhenkun; Wang, Liewei M; Boughey, Judy C; Kaufmann, Scott H; Goetz, Matthew Philip; Karnitz, Larry M; Hitosugi, Taro D.

In: Cell Metabolism, Vol. 28, No. 6, 04.12.2018, p. 833-847.e8.

Research output: Contribution to journalArticle

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AU - Wiese, Elizabeth K.

AU - Larson, Thomas R.

AU - Dai, Qing

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