Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation

Patricia Devaux, Veronika von Messling, Warangkhana Songsungthong, Christoph Springfeld, Roberto Cattaneo

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The measles virus (MV) P gene encodes three proteins: P, an essential polymerase cofactor, and C and V, which have multiple functions including immune evasion. We show here that the MV P protein also contributes to immune evasion, and that tyrosine 110 is required to block nuclear translocation of the signal transducer and activator of transcription factors (STAT) after interferon type I treatment. In particular, MV P inhibits STAT1 phosphorylation. This is shown not only by transient expression but also by reverse genetic analyses based on a new functional infectious cDNA derived from a MV vaccine vial (Moraten strain). Our study also identifies a conserved sequence around P protein tyrosine 110 as a candidate interaction site with a cellular protein.

Original languageEnglish (US)
Pages (from-to)72-83
Number of pages12
JournalVirology
Volume360
Issue number1
DOIs
StatePublished - Mar 30 2007

Fingerprint

Measles virus
Phosphoproteins
Tyrosine
Immune Evasion
Phosphorylation
Measles Vaccine
Reverse Genetics
Interferon Type I
Proteins
Conserved Sequence
Transducers
Transcription Factors
Complementary DNA
Genes

Keywords

  • Innate immunity
  • Interferon signaling
  • Measles virus
  • Phosphoprotein

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation. / Devaux, Patricia; von Messling, Veronika; Songsungthong, Warangkhana; Springfeld, Christoph; Cattaneo, Roberto.

In: Virology, Vol. 360, No. 1, 30.03.2007, p. 72-83.

Research output: Contribution to journalArticle

Devaux, Patricia ; von Messling, Veronika ; Songsungthong, Warangkhana ; Springfeld, Christoph ; Cattaneo, Roberto. / Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation. In: Virology. 2007 ; Vol. 360, No. 1. pp. 72-83.
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