Type-specific evolution of amyloid plaque and angiopathy in APPsw mice

Yasuo Harigaya, Yasushi Tomidokoro, Masaki Ikeda, Atsushi Sasaki, Takeshi Kawarabayashi, Etsuro Matsubara, Mitsuyasu Kanai, Takaomi C. Saido, Steven G. Younkin, Mikio Shoji

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

To clarify how Aβ deposits start in the brain, we examined the early to late stages of senile plaques and amyloid angiopathy in APPsw mice. All types of human senile plaques were observed in the mouse brains. The premature forms of cored plaques appeared first in the cerebral cortex of mice at 7-8 months old. Then, amyloid angiopathy emerged, followed by diffuse plaques consisting of Aβ1-42. Modifications of the N-terminus of Aβ were late phase phenomena. The premature forms of cored plaques were composed of central Aβ1-40 amyloid cores, surrounding amorphous Aβ1-42 deposits, and accumulation of Aβ1-42 in some peripheral cells. These cells were incorporated in amyloid cores, and these plaques developed to large cored plaques composed of Aβ1-40 and Aβ1-42. The size and number of cored plaques were increased with age. These findings indicate different evolution paths for cored plaques and diffuse plaques, and suggest the presence of a pathway that initiates with the intracellular accumulation of Aβ1-42 and leads to the development of classic plaques in human brain tissues.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalNeuroscience Letters
Volume395
Issue number1
DOIs
StatePublished - Feb 27 2006

Keywords

  • Alzheimer's disease
  • Amyloid angiopathy
  • Aβ40
  • Aβ42
  • Cored plaques
  • Diffuse plaques
  • Transgenic mice

ASJC Scopus subject areas

  • Neuroscience(all)

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    Harigaya, Y., Tomidokoro, Y., Ikeda, M., Sasaki, A., Kawarabayashi, T., Matsubara, E., Kanai, M., Saido, T. C., Younkin, S. G., & Shoji, M. (2006). Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters, 395(1), 37-41. https://doi.org/10.1016/j.neulet.2005.10.087