Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B

Alka Mary Mathai, Jacob Alexander, Fang Ying Kuo, Michael Torbenson, Paul E. Swanson, Matthew M. Yeh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present study was to investigate the association of ground-glass hepatocytes with (1) the histologic characteristics of HBV-related HCC and (2) the grade of inflammation, stage of fibrosis, serologic markers of HBV infection, HBV viral load, and α-fetoprotein levels. We evaluated 45 hepatectomy specimens from chronic HBV-infected patients: 25 with HCC and 20 without. In comparison with those without HCC, cases with HCC had a significantly higher prevalence of type II ground-glass hepatocytes (84% versus 55%, P =.0488), demonstrating a geographically clustered pattern (84% versus 45%, P =.0102) and exceeding type I in the individual samples (84% versus 35%, P =.0005). Type II ground-glass hepatocytes also had a statistically significant association with higher stages of fibrosis, being present in 21 cases (66%) with Ishak fibrosis stages 3 to 6 as compared with only 4 cases (31%) without type II ground-glass hepatocytes (P =.0176). In conclusion, type II ground-glass hepatocytes are more likely to be present in cases of HCC, growing in a clustered pattern, and are also associated with advanced fibrosis in chronic HBV infection. Our data suggest that a growth advantage or clonal proliferation of hepatocytes with mutant hepatitis B surface antigen may play a role in the pathogenesis of HBV-related HCC with clinical relevance.

Original languageEnglish (US)
Pages (from-to)1665-1671
Number of pages7
JournalHuman Pathology
Volume44
Issue number8
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Fingerprint

Chronic Hepatitis B
Glass
Hepatocytes
Hepatitis B virus
Hepatocellular Carcinoma
Fibrosis
Virus Diseases
Fetal Proteins
Hepatectomy
Hepatitis B Surface Antigens
Viral Load
Inflammation
Growth

Keywords

  • Ground-glass hepatocytes
  • Hepatitis B surface antigen
  • Hepatitis B virus infection
  • Hepatocellular carcinoma
  • Histopathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B. / Mathai, Alka Mary; Alexander, Jacob; Kuo, Fang Ying; Torbenson, Michael; Swanson, Paul E.; Yeh, Matthew M.

In: Human Pathology, Vol. 44, No. 8, 01.08.2013, p. 1665-1671.

Research output: Contribution to journalArticle

Mathai, Alka Mary ; Alexander, Jacob ; Kuo, Fang Ying ; Torbenson, Michael ; Swanson, Paul E. ; Yeh, Matthew M. / Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B. In: Human Pathology. 2013 ; Vol. 44, No. 8. pp. 1665-1671.
@article{4d1552360f2949abbd06870ef5154036,
title = "Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B",
abstract = "Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present study was to investigate the association of ground-glass hepatocytes with (1) the histologic characteristics of HBV-related HCC and (2) the grade of inflammation, stage of fibrosis, serologic markers of HBV infection, HBV viral load, and α-fetoprotein levels. We evaluated 45 hepatectomy specimens from chronic HBV-infected patients: 25 with HCC and 20 without. In comparison with those without HCC, cases with HCC had a significantly higher prevalence of type II ground-glass hepatocytes (84{\%} versus 55{\%}, P =.0488), demonstrating a geographically clustered pattern (84{\%} versus 45{\%}, P =.0102) and exceeding type I in the individual samples (84{\%} versus 35{\%}, P =.0005). Type II ground-glass hepatocytes also had a statistically significant association with higher stages of fibrosis, being present in 21 cases (66{\%}) with Ishak fibrosis stages 3 to 6 as compared with only 4 cases (31{\%}) without type II ground-glass hepatocytes (P =.0176). In conclusion, type II ground-glass hepatocytes are more likely to be present in cases of HCC, growing in a clustered pattern, and are also associated with advanced fibrosis in chronic HBV infection. Our data suggest that a growth advantage or clonal proliferation of hepatocytes with mutant hepatitis B surface antigen may play a role in the pathogenesis of HBV-related HCC with clinical relevance.",
keywords = "Ground-glass hepatocytes, Hepatitis B surface antigen, Hepatitis B virus infection, Hepatocellular carcinoma, Histopathology",
author = "Mathai, {Alka Mary} and Jacob Alexander and Kuo, {Fang Ying} and Michael Torbenson and Swanson, {Paul E.} and Yeh, {Matthew M.}",
year = "2013",
month = "8",
day = "1",
doi = "10.1016/j.humpath.2013.01.020",
language = "English (US)",
volume = "44",
pages = "1665--1671",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "8",

}

TY - JOUR

T1 - Type II ground-glass hepatocytes as a marker of hepatocellular carcinoma in chronic hepatitis B

AU - Mathai, Alka Mary

AU - Alexander, Jacob

AU - Kuo, Fang Ying

AU - Torbenson, Michael

AU - Swanson, Paul E.

AU - Yeh, Matthew M.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present study was to investigate the association of ground-glass hepatocytes with (1) the histologic characteristics of HBV-related HCC and (2) the grade of inflammation, stage of fibrosis, serologic markers of HBV infection, HBV viral load, and α-fetoprotein levels. We evaluated 45 hepatectomy specimens from chronic HBV-infected patients: 25 with HCC and 20 without. In comparison with those without HCC, cases with HCC had a significantly higher prevalence of type II ground-glass hepatocytes (84% versus 55%, P =.0488), demonstrating a geographically clustered pattern (84% versus 45%, P =.0102) and exceeding type I in the individual samples (84% versus 35%, P =.0005). Type II ground-glass hepatocytes also had a statistically significant association with higher stages of fibrosis, being present in 21 cases (66%) with Ishak fibrosis stages 3 to 6 as compared with only 4 cases (31%) without type II ground-glass hepatocytes (P =.0176). In conclusion, type II ground-glass hepatocytes are more likely to be present in cases of HCC, growing in a clustered pattern, and are also associated with advanced fibrosis in chronic HBV infection. Our data suggest that a growth advantage or clonal proliferation of hepatocytes with mutant hepatitis B surface antigen may play a role in the pathogenesis of HBV-related HCC with clinical relevance.

AB - Ground-glass hepatocytes are seen in chronic hepatitis B virus (HBV) infection and are known to harbor pre-S mutants, which are implicated in the pathogenesis of hepatocellular carcinoma (HCC). However, the association between ground-glass hepatocytes and HCC has yet to be clearly elucidated. The aim in the present study was to investigate the association of ground-glass hepatocytes with (1) the histologic characteristics of HBV-related HCC and (2) the grade of inflammation, stage of fibrosis, serologic markers of HBV infection, HBV viral load, and α-fetoprotein levels. We evaluated 45 hepatectomy specimens from chronic HBV-infected patients: 25 with HCC and 20 without. In comparison with those without HCC, cases with HCC had a significantly higher prevalence of type II ground-glass hepatocytes (84% versus 55%, P =.0488), demonstrating a geographically clustered pattern (84% versus 45%, P =.0102) and exceeding type I in the individual samples (84% versus 35%, P =.0005). Type II ground-glass hepatocytes also had a statistically significant association with higher stages of fibrosis, being present in 21 cases (66%) with Ishak fibrosis stages 3 to 6 as compared with only 4 cases (31%) without type II ground-glass hepatocytes (P =.0176). In conclusion, type II ground-glass hepatocytes are more likely to be present in cases of HCC, growing in a clustered pattern, and are also associated with advanced fibrosis in chronic HBV infection. Our data suggest that a growth advantage or clonal proliferation of hepatocytes with mutant hepatitis B surface antigen may play a role in the pathogenesis of HBV-related HCC with clinical relevance.

KW - Ground-glass hepatocytes

KW - Hepatitis B surface antigen

KW - Hepatitis B virus infection

KW - Hepatocellular carcinoma

KW - Histopathology

UR - http://www.scopus.com/inward/record.url?scp=84880330401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880330401&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2013.01.020

DO - 10.1016/j.humpath.2013.01.020

M3 - Article

C2 - 23574780

AN - SCOPUS:84880330401

VL - 44

SP - 1665

EP - 1671

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 8

ER -