Type II collagen induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera

P. H. Wooley, H. S. Luthra, W. P. Lafuse, A. Huse, J. M. Stuart, C. S. David

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70 Scopus citations

Abstract

Pretreatment of mice genetically susceptible to type II collagen-induced arthritis (CIA) with monoclonal or polyclonal antisera specific for I region gene products (Ia antigens) suppressed or delayed the onset of CIA, whereas pretreatment with anti-Ia to an irrelevant haplotype was without effect. The humoral response to type II collagen was transiently depressed 14 days after immunization but antibody levels did not differ significantly after 28 days. The peak delayed-type hypersensitivity to type II collagen was unaffected by anti-Ia treatment. Monoclonal antibody of one anti-Ia specificity enhanced both the antibody response and the arthritis incidence in one mouse strain.

Original languageEnglish (US)
Pages (from-to)2366-2374
Number of pages9
JournalJournal of Immunology
Volume134
Issue number4
StatePublished - Jun 19 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Wooley, P. H., Luthra, H. S., Lafuse, W. P., Huse, A., Stuart, J. M., & David, C. S. (1985). Type II collagen induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera. Journal of Immunology, 134(4), 2366-2374.