Type II collagen-induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type II collagen antibody or free native type II collagen

P. H. Wooley, H. S. Luthra, C. J. Krco, J. M. Stuart, C. S. David

Research output: Contribution to journalArticle

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The passive transfer of high levels of anti-type II collagen antibody from mice with type II collagen-induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub-arthritogenic doses of polyclonal antitype II collagen antibody, or non-arthritogenic monoclonal anti-type II collagen antibody may protect mice against the subsequent induction of arthritis by type II collagen. A protective effect was also observed in mice given free native type II collagen intravenously before the administration of collagen in an arthritogenic protocol.

Original languageEnglish (US)
Pages (from-to)1010-1017
Number of pages8
JournalArthritis and Rheumatism
Issue number9
StatePublished - 1984


ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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