Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates

P. H. Wooley, H. S. Luthra, J. M. Stuart, C. S. David

Research output: Contribution to journalArticle

571 Citations (Scopus)

Abstract

A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2(q) haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains to the I(q) locus. Type II collagen arthritis was observed in the (resistant x susceptible)F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)688-700
Number of pages13
JournalJournal of Experimental Medicine
Volume154
Issue number3
StatePublished - 1981

Fingerprint

Experimental Arthritis
Major Histocompatibility Complex
Antibodies
Arthritis
Immunogenetics
Collagen Type II
Haplotypes
Radioimmunoassay
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Animal Models
Injections

ASJC Scopus subject areas

  • Immunology

Cite this

Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates. / Wooley, P. H.; Luthra, H. S.; Stuart, J. M.; David, C. S.

In: Journal of Experimental Medicine, Vol. 154, No. 3, 1981, p. 688-700.

Research output: Contribution to journalArticle

Wooley, P. H. ; Luthra, H. S. ; Stuart, J. M. ; David, C. S. / Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates. In: Journal of Experimental Medicine. 1981 ; Vol. 154, No. 3. pp. 688-700.
@article{44066730dcad4b1f96f5b7dc039ebcda,
title = "Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates",
abstract = "A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2(q) haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains to the I(q) locus. Type II collagen arthritis was observed in the (resistant x susceptible)F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.",
author = "Wooley, {P. H.} and Luthra, {H. S.} and Stuart, {J. M.} and David, {C. S.}",
year = "1981",
language = "English (US)",
volume = "154",
pages = "688--700",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "3",

}

TY - JOUR

T1 - Type II collagen-induced arthritis in mice I. Major histocompatibility complex (I region) linkage and antibody correlates

AU - Wooley, P. H.

AU - Luthra, H. S.

AU - Stuart, J. M.

AU - David, C. S.

PY - 1981

Y1 - 1981

N2 - A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2(q) haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains to the I(q) locus. Type II collagen arthritis was observed in the (resistant x susceptible)F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.

AB - A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2(q) haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains to the I(q) locus. Type II collagen arthritis was observed in the (resistant x susceptible)F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.

UR - http://www.scopus.com/inward/record.url?scp=0019512029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019512029&partnerID=8YFLogxK

M3 - Article

VL - 154

SP - 688

EP - 700

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 3

ER -