Type I interferon pathway in adult and juvenile dermatomyositis

Emily C. Baechler, Hatice Bilgic, Ann M. Reed

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.

Original languageEnglish (US)
Article number249
JournalArthritis Research and Therapy
Volume13
Issue number6
DOIs
StatePublished - Dec 22 2011

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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