Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer

Phil A. Hart, Melena D. Bellin, Dana K. Andersen, David Bradley, Zobeida Cruz-Monserrate, Christopher E. Forsmark, Mark O. Goodarzi, Aida Habtezion, Murray Korc, Yogish C Kudva, Stephen J. Pandol, Dhiraj Yadav, Suresh T Chari

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.

Original languageEnglish (US)
Pages (from-to)226-237
Number of pages12
JournalThe Lancet Gastroenterology and Hepatology
Volume1
Issue number3
DOIs
StatePublished - 2016

Fingerprint

Chronic Pancreatitis
Pancreatic Neoplasms
Diabetes Mellitus
Exocrine Pancreas
Hyperglycemia
Adenocarcinoma
Pancreatic Diseases
Hemochromatosis
Cystic Fibrosis
Type 2 Diabetes Mellitus
Insulin Resistance
Epidemiology
Insulin

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer. / Hart, Phil A.; Bellin, Melena D.; Andersen, Dana K.; Bradley, David; Cruz-Monserrate, Zobeida; Forsmark, Christopher E.; Goodarzi, Mark O.; Habtezion, Aida; Korc, Murray; Kudva, Yogish C; Pandol, Stephen J.; Yadav, Dhiraj; Chari, Suresh T.

In: The Lancet Gastroenterology and Hepatology, Vol. 1, No. 3, 2016, p. 226-237.

Research output: Contribution to journalReview article

Hart, PA, Bellin, MD, Andersen, DK, Bradley, D, Cruz-Monserrate, Z, Forsmark, CE, Goodarzi, MO, Habtezion, A, Korc, M, Kudva, YC, Pandol, SJ, Yadav, D & Chari, ST 2016, 'Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer', The Lancet Gastroenterology and Hepatology, vol. 1, no. 3, pp. 226-237. https://doi.org/10.1016/S2468-1253(16)30106-6
Hart, Phil A. ; Bellin, Melena D. ; Andersen, Dana K. ; Bradley, David ; Cruz-Monserrate, Zobeida ; Forsmark, Christopher E. ; Goodarzi, Mark O. ; Habtezion, Aida ; Korc, Murray ; Kudva, Yogish C ; Pandol, Stephen J. ; Yadav, Dhiraj ; Chari, Suresh T. / Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer. In: The Lancet Gastroenterology and Hepatology. 2016 ; Vol. 1, No. 3. pp. 226-237.
@article{addaa6729d5d4398b9bbd014a144d759,
title = "Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer",
abstract = "Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.",
author = "Hart, {Phil A.} and Bellin, {Melena D.} and Andersen, {Dana K.} and David Bradley and Zobeida Cruz-Monserrate and Forsmark, {Christopher E.} and Goodarzi, {Mark O.} and Aida Habtezion and Murray Korc and Kudva, {Yogish C} and Pandol, {Stephen J.} and Dhiraj Yadav and Chari, {Suresh T}",
year = "2016",
doi = "10.1016/S2468-1253(16)30106-6",
language = "English (US)",
volume = "1",
pages = "226--237",
journal = "The Lancet Gastroenterology and Hepatology",
issn = "2468-1253",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer

AU - Hart, Phil A.

AU - Bellin, Melena D.

AU - Andersen, Dana K.

AU - Bradley, David

AU - Cruz-Monserrate, Zobeida

AU - Forsmark, Christopher E.

AU - Goodarzi, Mark O.

AU - Habtezion, Aida

AU - Korc, Murray

AU - Kudva, Yogish C

AU - Pandol, Stephen J.

AU - Yadav, Dhiraj

AU - Chari, Suresh T

PY - 2016

Y1 - 2016

N2 - Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.

AB - Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2 diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and subsequently by an inadequate compensatory insulin response. Diabetes can also develop as a direct consequence of other diseases, including diseases of the exocrine pancreas. Historically, diabetes due to diseases of the exocrine pancreas was described as pancreatogenic or pancreatogenous diabetes mellitus, but recent literature refers to it as type 3c diabetes. It is important to note that type 3c diabetes is not a single entity; it occurs because of a variety of exocrine pancreatic diseases with varying mechanisms of hyperglycaemia. The most commonly identified causes of type 3c diabetes are chronic pancreatitis, pancreatic ductal adenocarcinoma, haemochromatosis, cystic fibrosis, and previous pancreatic surgery. In this Review, we discuss the epidemiology, pathogenesis, and clinical relevance of type 3c diabetes secondary to chronic pancreatitis and pancreatic ductal adenocarcinoma, and highlight several important knowledge gaps.

UR - http://www.scopus.com/inward/record.url?scp=84996523898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996523898&partnerID=8YFLogxK

U2 - 10.1016/S2468-1253(16)30106-6

DO - 10.1016/S2468-1253(16)30106-6

M3 - Review article

C2 - 28404095

AN - SCOPUS:84996523898

VL - 1

SP - 226

EP - 237

JO - The Lancet Gastroenterology and Hepatology

JF - The Lancet Gastroenterology and Hepatology

SN - 2468-1253

IS - 3

ER -