Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America

Shannon M. Dunlay, Michael M. Givertz, David Aguilar, Larry A. Allen, Michael Chan, Akshay S. Desai, Anita Deswal, Victoria Vaughan Dickson, Mikhail N. Kosiborod, Carolyn L. Lekavich, Rozalina G. McCoy, Robert J. Mentz, Ileana L. Piña

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of morbidity and mortality in patients with established disease. Secular trends in the prevalence of diabetes mellitus and heart failure forecast a growing burden of disease and underscore the need for effective therapeutic strategies. Recent clinical trials have demonstrated the shared pathophysiology between diabetes mellitus and heart failure, the synergistic effect of managing both conditions, and the potential for diabetes mellitus therapies to modulate the risk of heart failure outcomes. This scientific statement on diabetes mellitus and heart failure summarizes the epidemiology, pathophysiology, and impact of diabetes mellitus and its control on outcomes in heart failure; reviews the approach to pharmacological therapy and lifestyle modification in patients with diabetes mellitus and heart failure; highlights the value of multidisciplinary interventions to improve clinical outcomes in this population; and outlines priorities for future research.

Original languageEnglish (US)
Pages (from-to)E294-E324
JournalCirculation
Volume140
Issue number7
DOIs
StatePublished - Aug 13 2019

Keywords

  • AHA Scientific Statement
  • Diabetes mellitus, type 2
  • Drug therapy
  • Heart failure
  • Lifestyle
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., McCoy, R. G., Mentz, R. J., & Piña, I. L. (2019). Type 2 diabetes mellitus and heart failure a scientific statement from the American Heart Association and the Heart Failure Society of America. Circulation, 140(7), E294-E324. https://doi.org/10.1161/CIR.0000000000000691