Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women

Rita Basu, Chiara Dalla Man, Marco Campioni, Ananda Basu, K Sreekumaran Nair, Michael Dennis Jensen, Sundeep Khosla, George Klee, Gianna Toffolo, Claudio Cobelli, Robert A. Rizza

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

To determine if dehydroepiandrosterone (DHEA) replacement improves insulin secretion, insulin action, and/or postprandial glucose metabolism, 112 elderly subjects with relative DHEA deficiency ingested a labeled mixed meal and underwent a frequently sampled intravenous glucose tolerance test before and after 2 years of either DHEA or placebo. Despite restoring DHEA sulphate concentrations to values observed in young men and women, the changes over time in fasting and postprandial glucose concentrations, meal appearance, glucose disposal, and endogenous glucose production were identical to those observed after 2 years of placebo. The change over time in postmeal and intravenous glucose tolerance test insulin and C-peptide concentrations did not differ in men treated with DHEA or placebo. In contrast, postmeal and intravenous glucose tolerance test change over time in insulin and C-peptide concentrations were greater (P < 0.05) in women after DHEA than after placebo. However, since DHEA tended to decrease insulin action, the change over time in disposition indexes did not differ between DHEA- and placebo-treated women, indicating that the slight increase in insulin secretion was a compensatory response to a slight decrease in insulin action. We conclude that 2 years of replacement of DHEA in elderly men and women does not improve insulin secretion, insulin action, or the pattern of postprandial glucose metabolism.

Original languageEnglish (US)
Pages (from-to)753-766
Number of pages14
JournalDiabetes
Volume56
Issue number3
DOIs
StatePublished - Mar 2007

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Dehydroepiandrosterone
Insulin
Glucose
Placebos
Glucose Tolerance Test
Therapeutics
C-Peptide
Meals
Dehydroepiandrosterone Sulfate
Fasting

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. / Basu, Rita; Man, Chiara Dalla; Campioni, Marco; Basu, Ananda; Nair, K Sreekumaran; Jensen, Michael Dennis; Khosla, Sundeep; Klee, George; Toffolo, Gianna; Cobelli, Claudio; Rizza, Robert A.

In: Diabetes, Vol. 56, No. 3, 03.2007, p. 753-766.

Research output: Contribution to journalArticle

Basu, Rita ; Man, Chiara Dalla ; Campioni, Marco ; Basu, Ananda ; Nair, K Sreekumaran ; Jensen, Michael Dennis ; Khosla, Sundeep ; Klee, George ; Toffolo, Gianna ; Cobelli, Claudio ; Rizza, Robert A. / Two years of treatment with dehydroepiandrosterone does not improve insulin secretion, insulin action, or postprandial glucose turnover in elderly men or women. In: Diabetes. 2007 ; Vol. 56, No. 3. pp. 753-766.
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