Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction

Nicolas Sananes, Rogelio Cruz-Martinez, Romain Favre, Ricardo Ordorica-Flores, Raphaël Moog, Ariane Zaloszy, Amilcar Martins Giron, Rodrigo Ruano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: Our objective is to report long-term outcome after fetal cystoscopy for lower urinary tract obstruction (LUTO), as well as to investigate the accuracy of fetal cystoscopy in diagnosing the cause of bladder outlet obstruction. Methods: This is a retrospective cohort study of all fetuses who underwent cystoscopy for prenatal diagnosis of LUTO in three tertiary referral centers. Fetal diagnostic cystoscopy was performed to determine prenatally the cause of LUTO and to ablate the posterior urethral valves (PUV). Results: A total of 50 fetal cystoscopies were performed, revealing PUV in 31 (62%) fetuses, urethral atresia (UA) in 14 (28%) fetuses, and urethral stenosis (US) in 5 (10%) fetuses. Two fetuses had trisomy 18 diagnosed after fetal cystoscopy and were excluded from the present analysis. Fetal cystoscopy was accurate in the diagnosis of the etiology of LUTO in 32/35 (91.4%). There were no survivors in the UA group. One fetus with US underwent urethral stenting and survived with normal renal function at 2years of life. Among the infants with PUV, 17/30 (56.7%) infants survived, and 13/17 (76.5%) had normal renal function at 1year of life; 15/28 (53.6%) infants survived, and 11/15 (73.3%) had normal renal function at 2years. Conclusions: Fetal cystoscopy is accurate in the diagnosis of the etiology of LUTO and serves as a guide to the specific prenatal treatment. This procedure is associated with modest long-term survival (54%) but with adequate preserved normal renal function in two thirds of the infants among fetuses with PUV.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalPrenatal Diagnosis
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Cystoscopy
Urinary Tract
Fetus
Kidney
Urethral Stricture
Therapeutics
Urinary Bladder Neck Obstruction
Prenatal Diagnosis
Tertiary Care Centers
Cohort Studies
Retrospective Studies

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

Sananes, N., Cruz-Martinez, R., Favre, R., Ordorica-Flores, R., Moog, R., Zaloszy, A., ... Ruano, R. (2016). Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. Prenatal Diagnosis, 36(4), 297-303. https://doi.org/10.1002/pd.4771

Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. / Sananes, Nicolas; Cruz-Martinez, Rogelio; Favre, Romain; Ordorica-Flores, Ricardo; Moog, Raphaël; Zaloszy, Ariane; Giron, Amilcar Martins; Ruano, Rodrigo.

In: Prenatal Diagnosis, Vol. 36, No. 4, 01.04.2016, p. 297-303.

Research output: Contribution to journalArticle

Sananes, N, Cruz-Martinez, R, Favre, R, Ordorica-Flores, R, Moog, R, Zaloszy, A, Giron, AM & Ruano, R 2016, 'Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction', Prenatal Diagnosis, vol. 36, no. 4, pp. 297-303. https://doi.org/10.1002/pd.4771
Sananes N, Cruz-Martinez R, Favre R, Ordorica-Flores R, Moog R, Zaloszy A et al. Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. Prenatal Diagnosis. 2016 Apr 1;36(4):297-303. https://doi.org/10.1002/pd.4771
Sananes, Nicolas ; Cruz-Martinez, Rogelio ; Favre, Romain ; Ordorica-Flores, Ricardo ; Moog, Raphaël ; Zaloszy, Ariane ; Giron, Amilcar Martins ; Ruano, Rodrigo. / Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction. In: Prenatal Diagnosis. 2016 ; Vol. 36, No. 4. pp. 297-303.
@article{2e28e5da082243b6b3833a04fedd54c1,
title = "Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction",
abstract = "Objectives: Our objective is to report long-term outcome after fetal cystoscopy for lower urinary tract obstruction (LUTO), as well as to investigate the accuracy of fetal cystoscopy in diagnosing the cause of bladder outlet obstruction. Methods: This is a retrospective cohort study of all fetuses who underwent cystoscopy for prenatal diagnosis of LUTO in three tertiary referral centers. Fetal diagnostic cystoscopy was performed to determine prenatally the cause of LUTO and to ablate the posterior urethral valves (PUV). Results: A total of 50 fetal cystoscopies were performed, revealing PUV in 31 (62{\%}) fetuses, urethral atresia (UA) in 14 (28{\%}) fetuses, and urethral stenosis (US) in 5 (10{\%}) fetuses. Two fetuses had trisomy 18 diagnosed after fetal cystoscopy and were excluded from the present analysis. Fetal cystoscopy was accurate in the diagnosis of the etiology of LUTO in 32/35 (91.4{\%}). There were no survivors in the UA group. One fetus with US underwent urethral stenting and survived with normal renal function at 2years of life. Among the infants with PUV, 17/30 (56.7{\%}) infants survived, and 13/17 (76.5{\%}) had normal renal function at 1year of life; 15/28 (53.6{\%}) infants survived, and 11/15 (73.3{\%}) had normal renal function at 2years. Conclusions: Fetal cystoscopy is accurate in the diagnosis of the etiology of LUTO and serves as a guide to the specific prenatal treatment. This procedure is associated with modest long-term survival (54{\%}) but with adequate preserved normal renal function in two thirds of the infants among fetuses with PUV.",
author = "Nicolas Sananes and Rogelio Cruz-Martinez and Romain Favre and Ricardo Ordorica-Flores and Rapha{\"e}l Moog and Ariane Zaloszy and Giron, {Amilcar Martins} and Rodrigo Ruano",
year = "2016",
month = "4",
day = "1",
doi = "10.1002/pd.4771",
language = "English (US)",
volume = "36",
pages = "297--303",
journal = "Prenatal Diagnosis",
issn = "0197-3851",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

TY - JOUR

T1 - Two-year outcomes after diagnostic and therapeutic fetal cystoscopy for lower urinary tract obstruction

AU - Sananes, Nicolas

AU - Cruz-Martinez, Rogelio

AU - Favre, Romain

AU - Ordorica-Flores, Ricardo

AU - Moog, Raphaël

AU - Zaloszy, Ariane

AU - Giron, Amilcar Martins

AU - Ruano, Rodrigo

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Objectives: Our objective is to report long-term outcome after fetal cystoscopy for lower urinary tract obstruction (LUTO), as well as to investigate the accuracy of fetal cystoscopy in diagnosing the cause of bladder outlet obstruction. Methods: This is a retrospective cohort study of all fetuses who underwent cystoscopy for prenatal diagnosis of LUTO in three tertiary referral centers. Fetal diagnostic cystoscopy was performed to determine prenatally the cause of LUTO and to ablate the posterior urethral valves (PUV). Results: A total of 50 fetal cystoscopies were performed, revealing PUV in 31 (62%) fetuses, urethral atresia (UA) in 14 (28%) fetuses, and urethral stenosis (US) in 5 (10%) fetuses. Two fetuses had trisomy 18 diagnosed after fetal cystoscopy and were excluded from the present analysis. Fetal cystoscopy was accurate in the diagnosis of the etiology of LUTO in 32/35 (91.4%). There were no survivors in the UA group. One fetus with US underwent urethral stenting and survived with normal renal function at 2years of life. Among the infants with PUV, 17/30 (56.7%) infants survived, and 13/17 (76.5%) had normal renal function at 1year of life; 15/28 (53.6%) infants survived, and 11/15 (73.3%) had normal renal function at 2years. Conclusions: Fetal cystoscopy is accurate in the diagnosis of the etiology of LUTO and serves as a guide to the specific prenatal treatment. This procedure is associated with modest long-term survival (54%) but with adequate preserved normal renal function in two thirds of the infants among fetuses with PUV.

AB - Objectives: Our objective is to report long-term outcome after fetal cystoscopy for lower urinary tract obstruction (LUTO), as well as to investigate the accuracy of fetal cystoscopy in diagnosing the cause of bladder outlet obstruction. Methods: This is a retrospective cohort study of all fetuses who underwent cystoscopy for prenatal diagnosis of LUTO in three tertiary referral centers. Fetal diagnostic cystoscopy was performed to determine prenatally the cause of LUTO and to ablate the posterior urethral valves (PUV). Results: A total of 50 fetal cystoscopies were performed, revealing PUV in 31 (62%) fetuses, urethral atresia (UA) in 14 (28%) fetuses, and urethral stenosis (US) in 5 (10%) fetuses. Two fetuses had trisomy 18 diagnosed after fetal cystoscopy and were excluded from the present analysis. Fetal cystoscopy was accurate in the diagnosis of the etiology of LUTO in 32/35 (91.4%). There were no survivors in the UA group. One fetus with US underwent urethral stenting and survived with normal renal function at 2years of life. Among the infants with PUV, 17/30 (56.7%) infants survived, and 13/17 (76.5%) had normal renal function at 1year of life; 15/28 (53.6%) infants survived, and 11/15 (73.3%) had normal renal function at 2years. Conclusions: Fetal cystoscopy is accurate in the diagnosis of the etiology of LUTO and serves as a guide to the specific prenatal treatment. This procedure is associated with modest long-term survival (54%) but with adequate preserved normal renal function in two thirds of the infants among fetuses with PUV.

UR - http://www.scopus.com/inward/record.url?scp=84959016981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959016981&partnerID=8YFLogxK

U2 - 10.1002/pd.4771

DO - 10.1002/pd.4771

M3 - Article

C2 - 26739350

AN - SCOPUS:84959016981

VL - 36

SP - 297

EP - 303

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

SN - 0197-3851

IS - 4

ER -