Two enabling architectures for DNA-templated organic synthesis

Zev J. Gartner, Rozalina McCoy, Christopher T. Calderone, David R. Liu

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

Original languageEnglish (US)
Pages (from-to)1370-1375
Number of pages6
JournalAngewandte Chemie - International Edition
Volume42
Issue number12
DOIs
StatePublished - Mar 28 2003
Externally publishedYes

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Keywords

  • Bioorganic chemistry
  • Combinatorial chemistry
  • DNA
  • Template synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Two enabling architectures for DNA-templated organic synthesis. / Gartner, Zev J.; McCoy, Rozalina; Calderone, Christopher T.; Liu, David R.

In: Angewandte Chemie - International Edition, Vol. 42, No. 12, 28.03.2003, p. 1370-1375.

Research output: Contribution to journalArticle

Gartner, Zev J. ; McCoy, Rozalina ; Calderone, Christopher T. ; Liu, David R. / Two enabling architectures for DNA-templated organic synthesis. In: Angewandte Chemie - International Edition. 2003 ; Vol. 42, No. 12. pp. 1370-1375.
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