Two enabling architectures for DNA-templated organic synthesis

Zev J. Gartner; Rozalina Grubina; Christopher T. Calderone; David R. Liu

doi:10.1002/anie.200390351

Two enabling architectures for DNA-templated organic synthesis

Zev J. Gartner, Rozalina Grubina, Christopher T. Calderone, David R. Liu

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

Original language	English (US)
Pages (from-to)	1370-1375
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	12
DOIs	https://doi.org/10.1002/anie.200390351
State	Published - Mar 28 2003

Keywords

Bioorganic chemistry
Combinatorial chemistry
DNA
Template synthesis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200390351

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AU - Grubina, Rozalina

AU - Calderone, Christopher T.

AU - Liu, David R.

PY - 2003/3/28

Y1 - 2003/3/28

N2 - Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

AB - Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

KW - Bioorganic chemistry

KW - Combinatorial chemistry

KW - DNA

KW - Template synthesis

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Two enabling architectures for DNA-templated organic synthesis

Abstract

Keywords

ASJC Scopus subject areas

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