Two-dimensional digital video ankle motion analysis for assessment of function in the rat sciatic nerve model

Godard C. De Ruiter, Robert J. Spinner, Awad O. Alaid, Anthony J. Koch, Huan D Wang, M. J A Malessy, Bradford L. Currier, Michael J Yaszemski, Kenton R Kaufman, Anthony John Windebank

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Ankle motion analysis may provide a better method to assess function in the rat sciatic nerve model than the standard method, the sciatic functional index (SFI), but it is not widely used in experiments on nerve regeneration possibly because of complicated analysis. In this study, we investigated the practical use of a two-dimensional (2D) digital video motion analysis system. Reproducibility was investigated in normal rats. Recovery of ankle motion was analyzed after sciatic, tibial, and peroneal nerve crush injury. Results were compared with scores for the SFI. Results were not significantly different from animal-to-animal and day-to-day. Interobserver variability also was small. In the analysis of recovery after separate nerve crush injuries, subtle differences in ankle plantar flexion and dorsiflexion could be detected. The method was also more sensitive than the SFI: whereas scores for the SFI had returned to normal 4 weeks after sciatic nerve crush injury, the ankle angle at mid-stance was still significantly different from that in sham-operated animals 6 weeks after the injury. 2D digital video ankle motion analysis is a practical and sensitive method to assess function in the rat sciatic nerve model.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalJournal of the Peripheral Nervous System
Volume12
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Sciatic Nerve
Ankle
Nerve Crush
Tibial Nerve
Peroneal Nerve
Nerve Regeneration
Observer Variation
Wounds and Injuries
Crush Injuries

Keywords

  • Nerve injury
  • Nerve regeneration
  • Nerve repair
  • Sciatic function index
  • Walking track analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Two-dimensional digital video ankle motion analysis for assessment of function in the rat sciatic nerve model. / De Ruiter, Godard C.; Spinner, Robert J.; Alaid, Awad O.; Koch, Anthony J.; Wang, Huan D; Malessy, M. J A; Currier, Bradford L.; Yaszemski, Michael J; Kaufman, Kenton R; Windebank, Anthony John.

In: Journal of the Peripheral Nervous System, Vol. 12, No. 3, 09.2007, p. 216-222.

Research output: Contribution to journalArticle

De Ruiter, Godard C. ; Spinner, Robert J. ; Alaid, Awad O. ; Koch, Anthony J. ; Wang, Huan D ; Malessy, M. J A ; Currier, Bradford L. ; Yaszemski, Michael J ; Kaufman, Kenton R ; Windebank, Anthony John. / Two-dimensional digital video ankle motion analysis for assessment of function in the rat sciatic nerve model. In: Journal of the Peripheral Nervous System. 2007 ; Vol. 12, No. 3. pp. 216-222.
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