TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION

ConorM Burke, JohnC Baldwin, AdrianJ Morris, NormanE Shumway, James Theodore, HenryD Tazelaar, Christopher Mcgregor, EugeneD Robin, StuartW Jamieson

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Between March, 1981, and August, 1985, twenty-eight heart-lung transplant operations were done in 27 patients at a single institution. 8 patients died in the perioperative period and adhesions related to previous thoracic surgery proved to be a major risk factor for postoperative haemorrhage. Obliterative bronchiolitis developed in half of the 20 long-term survivors, a mean of 11·2 months (range 2-35 months) after surgery: 4 of these patients died, 3 are functionally limited, 2 were successfully treated with corticosteroids, and the remaining patient was successfully retransplanted. The other 10 long-term survivors returned to a normal life with essentially normal pulmonary function measured at a mean of 22·6 months (range 4-42 months) after transplantation. All the surviving patients have evidence of renal impairment related to cyclosporin nephrotoxicity. The results indicate that, although heart-lung transplantation is compatible with essentially normal long-term pulmonary function, the procedure should not yet be regarded as a routine clinical intervention.

Original languageEnglish (US)
Pages (from-to)517-519
Number of pages3
JournalThe Lancet
Volume327
Issue number8480
DOIs
StatePublished - Mar 8 1986
Externally publishedYes

Fingerprint

Heart-Lung Transplantation
Lung
Survivors
Postoperative Hemorrhage
Bronchiolitis
Perioperative Period
Cyclosporine
Thoracic Surgery
Adrenal Cortex Hormones
Transplantation
Transplants
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Burke, C., Baldwin, J., Morris, A., Shumway, N., Theodore, J., Tazelaar, H., ... Jamieson, S. (1986). TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION. The Lancet, 327(8480), 517-519. https://doi.org/10.1016/S0140-6736(86)90881-0

TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION. / Burke, ConorM; Baldwin, JohnC; Morris, AdrianJ; Shumway, NormanE; Theodore, James; Tazelaar, HenryD; Mcgregor, Christopher; Robin, EugeneD; Jamieson, StuartW.

In: The Lancet, Vol. 327, No. 8480, 08.03.1986, p. 517-519.

Research output: Contribution to journalArticle

Burke, C, Baldwin, J, Morris, A, Shumway, N, Theodore, J, Tazelaar, H, Mcgregor, C, Robin, E & Jamieson, S 1986, 'TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION', The Lancet, vol. 327, no. 8480, pp. 517-519. https://doi.org/10.1016/S0140-6736(86)90881-0
Burke C, Baldwin J, Morris A, Shumway N, Theodore J, Tazelaar H et al. TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION. The Lancet. 1986 Mar 8;327(8480):517-519. https://doi.org/10.1016/S0140-6736(86)90881-0
Burke, ConorM ; Baldwin, JohnC ; Morris, AdrianJ ; Shumway, NormanE ; Theodore, James ; Tazelaar, HenryD ; Mcgregor, Christopher ; Robin, EugeneD ; Jamieson, StuartW. / TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION. In: The Lancet. 1986 ; Vol. 327, No. 8480. pp. 517-519.
@article{ae14590dfd6749dcb8982ed83b452ca1,
title = "TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION",
abstract = "Between March, 1981, and August, 1985, twenty-eight heart-lung transplant operations were done in 27 patients at a single institution. 8 patients died in the perioperative period and adhesions related to previous thoracic surgery proved to be a major risk factor for postoperative haemorrhage. Obliterative bronchiolitis developed in half of the 20 long-term survivors, a mean of 11·2 months (range 2-35 months) after surgery: 4 of these patients died, 3 are functionally limited, 2 were successfully treated with corticosteroids, and the remaining patient was successfully retransplanted. The other 10 long-term survivors returned to a normal life with essentially normal pulmonary function measured at a mean of 22·6 months (range 4-42 months) after transplantation. All the surviving patients have evidence of renal impairment related to cyclosporin nephrotoxicity. The results indicate that, although heart-lung transplantation is compatible with essentially normal long-term pulmonary function, the procedure should not yet be regarded as a routine clinical intervention.",
author = "ConorM Burke and JohnC Baldwin and AdrianJ Morris and NormanE Shumway and James Theodore and HenryD Tazelaar and Christopher Mcgregor and EugeneD Robin and StuartW Jamieson",
year = "1986",
month = "3",
day = "8",
doi = "10.1016/S0140-6736(86)90881-0",
language = "English (US)",
volume = "327",
pages = "517--519",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8480",

}

TY - JOUR

T1 - TWENTY-EIGHT CASES OF HUMAN HEART-LUNG TRANSPLANTATION

AU - Burke, ConorM

AU - Baldwin, JohnC

AU - Morris, AdrianJ

AU - Shumway, NormanE

AU - Theodore, James

AU - Tazelaar, HenryD

AU - Mcgregor, Christopher

AU - Robin, EugeneD

AU - Jamieson, StuartW

PY - 1986/3/8

Y1 - 1986/3/8

N2 - Between March, 1981, and August, 1985, twenty-eight heart-lung transplant operations were done in 27 patients at a single institution. 8 patients died in the perioperative period and adhesions related to previous thoracic surgery proved to be a major risk factor for postoperative haemorrhage. Obliterative bronchiolitis developed in half of the 20 long-term survivors, a mean of 11·2 months (range 2-35 months) after surgery: 4 of these patients died, 3 are functionally limited, 2 were successfully treated with corticosteroids, and the remaining patient was successfully retransplanted. The other 10 long-term survivors returned to a normal life with essentially normal pulmonary function measured at a mean of 22·6 months (range 4-42 months) after transplantation. All the surviving patients have evidence of renal impairment related to cyclosporin nephrotoxicity. The results indicate that, although heart-lung transplantation is compatible with essentially normal long-term pulmonary function, the procedure should not yet be regarded as a routine clinical intervention.

AB - Between March, 1981, and August, 1985, twenty-eight heart-lung transplant operations were done in 27 patients at a single institution. 8 patients died in the perioperative period and adhesions related to previous thoracic surgery proved to be a major risk factor for postoperative haemorrhage. Obliterative bronchiolitis developed in half of the 20 long-term survivors, a mean of 11·2 months (range 2-35 months) after surgery: 4 of these patients died, 3 are functionally limited, 2 were successfully treated with corticosteroids, and the remaining patient was successfully retransplanted. The other 10 long-term survivors returned to a normal life with essentially normal pulmonary function measured at a mean of 22·6 months (range 4-42 months) after transplantation. All the surviving patients have evidence of renal impairment related to cyclosporin nephrotoxicity. The results indicate that, although heart-lung transplantation is compatible with essentially normal long-term pulmonary function, the procedure should not yet be regarded as a routine clinical intervention.

UR - http://www.scopus.com/inward/record.url?scp=0022623119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022623119&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(86)90881-0

DO - 10.1016/S0140-6736(86)90881-0

M3 - Article

VL - 327

SP - 517

EP - 519

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8480

ER -