TWEAK and Fn14

New molecular targets for cancer therapy?

Jeffrey A. Winkles, Nhan Tran, Michael E. Berens

Research output: Contribution to journalShort survey

56 Citations (Scopus)

Abstract

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor (TNF) superfamily of structurally related cytokines. Full-length, membrane-anchored TWEAK can be found on the surface of many cell types and a smaller, biologically active form, generated via proteolytic processing, has also been detected in the extracellular milieu. TWEAK acts via binding to a recently identified TNF receptor superfamily member named fibroblast growth factor-inducible 14 (Fn14). It has been demonstrated that TWEAK binding to the Fn14 receptor, or constitutive Fn14 overexpression, activates the nuclear factor-κB signaling pathway, which is known to play an important role in immune and inflammatory processes, oncogenesis, and cancer therapy resistance. In this article, we review recent studies indicating that TWEAK and Fn14 may be potential regulators of human tumorigenesis.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalCancer Letters
Volume235
Issue number1
DOIs
StatePublished - Apr 8 2006
Externally publishedYes

Fingerprint

Carcinogenesis
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptors
Neoplasms
Apoptosis
Cytokines
Membranes
Therapeutics
fibroblast growth factor 14

Keywords

  • Angiogenesis
  • Cancer
  • Endothelial cell
  • Fn14
  • TNF
  • Tumor
  • TWEAK

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

TWEAK and Fn14 : New molecular targets for cancer therapy? / Winkles, Jeffrey A.; Tran, Nhan; Berens, Michael E.

In: Cancer Letters, Vol. 235, No. 1, 08.04.2006, p. 11-17.

Research output: Contribution to journalShort survey

Winkles, Jeffrey A. ; Tran, Nhan ; Berens, Michael E. / TWEAK and Fn14 : New molecular targets for cancer therapy?. In: Cancer Letters. 2006 ; Vol. 235, No. 1. pp. 11-17.
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