Tuning pharmacokinetics and biodistribution of a targeted drug delivery system through incorporation of a passive targeting component

Rachel A. Kudgus, Chad A. Walden, Renee M. McGovern, Joel M. Reid, J. David Robertson, Priyabrata Mukherjee

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Major challenges in the development of drug delivery systems (DDSs) have been the short half-life, poor bioavailability, insufficient accumulation and penetration of the DDSs into the tumor tissue. Understanding the pharmacokinetic (PK) parameters of the DDS is essential to overcome these challenges. Herein we investigate how surface chemistry affects the PK profile and organ distribution of a gold nanoparticle-based DDS containing both a passive and active targeting moiety via two common routes of administration: intravenous and intraperitoneal injections. Using LC/MS/MS, ELISA and INAA we report the half-life, peak plasma concentrations, area under the curve, ability to cross the peritoneal barrier and biodistribution of the nanoconjugates. The results highlight the design criteria for fine-tuning the PK parameters of a targeted drug delivery system that exploits the benefits of both active and passive targeting.

Original languageEnglish (US)
Article number5669
JournalScientific reports
Volume4
DOIs
StatePublished - Jul 11 2014

ASJC Scopus subject areas

  • General

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