Tunable tissue scaffolds fabricated by in situ crosslink in phase separation system

Xifeng Liu, Wenjian Chen, Carl T. Gustafson, A. Lee Miller, Brian E. Waletzki, Michael J. Yaszemski, Lichun Lu

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Three-dimensional (3-D) scaffolds with intrinsic porous structures are desirable in various tissue regeneration applications. In this study, a unique method that combines thermally induced phase separation with a photocrosslinking process was developed for the fabrication of 3-D crosslinked polymer scaffolds with densely interconnected porous structures. Biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) with crosslinkable fumarate bonds were used as the structural polymer material and a dioxane/water binary system was applied for the phase separation. By altering the polymer composition (9, 5 and 3 wt%), different types of scaffolds with distinct morphology, mechanical strength, degradation rate, cell growth and morphology, and extracellular matrix production were fabricated. These crosslinked 3-D porous scaffolds with tunable strength and biological responses show promise for potential applications in regenerative therapies, including bone and neural tissue engineering.

Original languageEnglish (US)
Pages (from-to)100824-100833
Number of pages10
JournalRSC Advances
Issue number122
StatePublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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