Tumor volume discrepancies between FDG-PET and MRI for cervical cancer

Daniel J. Ma, Jian Ming Zhu, Perry W. Grigsby

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To compare the MRI-defined gross tumor volume (MR-GTV) to the metabolic tumor volume (Metabolic GTV) defined by FDG-PET in patients with cervical cancer. Materials and methods: Forty seven patients with cervical cancer underwent FDG-PET/CT and MRI simulations. FDG-PET images were acquired with a spatial resolution of 5 mm. MR imaging was performed on a 1.5 Tesla scanner. MR-GTV was contoured on the T2 axial images while Metabolic GTV was auto-contoured using a 40% SUV threshold. Tumor volumes were compared. Results: Eighteen patients (38.3%) had tumors ≥62 cc on MRI. Seventeen patients (36.2%) had tumors ≥14 and <62 cc, while 12 patients (25.5%) had tumors <14 cc. 83% of patients in the ≥62 cc, 23.5% in the 14-62 cc, and 16.7% in the <14 cc cohort had Grade 3 images as defined by Dimopoulos et al. In the ≥62 cc cohort, MR-GTV and Metabolic GTV had a lesion coverage factor of 0.68 (mean MR-GTV vol 124.1, mean Metabolic GTV vol 119.9 cc). This fell to 0.51 (32.4, 33.1 cc) for the 14-62 cc, and 0.28 (8.4, 8.7 cc) for the <14 cc cohort. These differences were statistically significant on ANOVA testing (p < 0.001). Conclusions: MRI provided better visualization of larger tumors than smaller tumors in reference to FDG-PET/CT. FDG-PET/CT visualized tumor volumes different from T2-weighted MRI, especially in tumors <14 cc in regard to location.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalRadiotherapy and Oncology
Volume98
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

Fingerprint

Tumor Burden
Uterine Cervical Neoplasms
Neoplasms
Analysis of Variance

Keywords

  • Cervical cancer
  • FDG-PET
  • IMRT
  • MRI

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Tumor volume discrepancies between FDG-PET and MRI for cervical cancer. / Ma, Daniel J.; Zhu, Jian Ming; Grigsby, Perry W.

In: Radiotherapy and Oncology, Vol. 98, No. 1, 01.2011, p. 139-142.

Research output: Contribution to journalArticle

Ma, Daniel J. ; Zhu, Jian Ming ; Grigsby, Perry W. / Tumor volume discrepancies between FDG-PET and MRI for cervical cancer. In: Radiotherapy and Oncology. 2011 ; Vol. 98, No. 1. pp. 139-142.
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abstract = "Purpose: To compare the MRI-defined gross tumor volume (MR-GTV) to the metabolic tumor volume (Metabolic GTV) defined by FDG-PET in patients with cervical cancer. Materials and methods: Forty seven patients with cervical cancer underwent FDG-PET/CT and MRI simulations. FDG-PET images were acquired with a spatial resolution of 5 mm. MR imaging was performed on a 1.5 Tesla scanner. MR-GTV was contoured on the T2 axial images while Metabolic GTV was auto-contoured using a 40{\%} SUV threshold. Tumor volumes were compared. Results: Eighteen patients (38.3{\%}) had tumors ≥62 cc on MRI. Seventeen patients (36.2{\%}) had tumors ≥14 and <62 cc, while 12 patients (25.5{\%}) had tumors <14 cc. 83{\%} of patients in the ≥62 cc, 23.5{\%} in the 14-62 cc, and 16.7{\%} in the <14 cc cohort had Grade 3 images as defined by Dimopoulos et al. In the ≥62 cc cohort, MR-GTV and Metabolic GTV had a lesion coverage factor of 0.68 (mean MR-GTV vol 124.1, mean Metabolic GTV vol 119.9 cc). This fell to 0.51 (32.4, 33.1 cc) for the 14-62 cc, and 0.28 (8.4, 8.7 cc) for the <14 cc cohort. These differences were statistically significant on ANOVA testing (p < 0.001). Conclusions: MRI provided better visualization of larger tumors than smaller tumors in reference to FDG-PET/CT. FDG-PET/CT visualized tumor volumes different from T2-weighted MRI, especially in tumors <14 cc in regard to location.",
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AB - Purpose: To compare the MRI-defined gross tumor volume (MR-GTV) to the metabolic tumor volume (Metabolic GTV) defined by FDG-PET in patients with cervical cancer. Materials and methods: Forty seven patients with cervical cancer underwent FDG-PET/CT and MRI simulations. FDG-PET images were acquired with a spatial resolution of 5 mm. MR imaging was performed on a 1.5 Tesla scanner. MR-GTV was contoured on the T2 axial images while Metabolic GTV was auto-contoured using a 40% SUV threshold. Tumor volumes were compared. Results: Eighteen patients (38.3%) had tumors ≥62 cc on MRI. Seventeen patients (36.2%) had tumors ≥14 and <62 cc, while 12 patients (25.5%) had tumors <14 cc. 83% of patients in the ≥62 cc, 23.5% in the 14-62 cc, and 16.7% in the <14 cc cohort had Grade 3 images as defined by Dimopoulos et al. In the ≥62 cc cohort, MR-GTV and Metabolic GTV had a lesion coverage factor of 0.68 (mean MR-GTV vol 124.1, mean Metabolic GTV vol 119.9 cc). This fell to 0.51 (32.4, 33.1 cc) for the 14-62 cc, and 0.28 (8.4, 8.7 cc) for the <14 cc cohort. These differences were statistically significant on ANOVA testing (p < 0.001). Conclusions: MRI provided better visualization of larger tumors than smaller tumors in reference to FDG-PET/CT. FDG-PET/CT visualized tumor volumes different from T2-weighted MRI, especially in tumors <14 cc in regard to location.

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